Rhobtb3 Rho-related BTB domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhobtb3provided by MGI
Official Full Name: Rho-related BTB domain containing 3provided by MGI
Primary source: MGI:MGI:1920546
See related: Ensembl:ENSMUSG00000021589 AllianceGenome:MGI:1920546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0878; 1700040C17Rik; 2610033K01Rik; 4930503C18Rik
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Acts upstream of or within male gonad development. Located in cytoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; respiratory system; and skeletal musculature. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 11.7), limb E14.5 (RPKM 9.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.95 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (76017656..76092054, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (75869537..75943824, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
Title: Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.
genetic deletion of Rhobtb3 leads to subtle alterations in alpha-granule secretion and adhesion to collagen without significant effects on hemostasis in vivo.
Title: Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3.
embryo and adult gene expression profiling
Title: Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.
The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
Title: MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

25.MMHAP63FRA10.seq (e-PCR)
- UniSTS:123695

AW208826 (e-PCR)
- UniSTS:180561

RH126470 (e-PCR)
- UniSTS:163178

RH136153 (e-PCR)
- UniSTS:210148

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho-related BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418860.1 → NP_001405789.1 rho-related BTB domain-containing protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC122242, AC158356
NM_028493.3 → NP_082769.1 rho-related BTB domain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_082769.1

Status: VALIDATED

Source sequence(s)

AC122242, AC158356

Consensus CDS

CCDS26652.1

UniProtKB/Swiss-Prot

Q05DP2, Q3UTS4, Q80X55, Q9CTN4, Q9CVT0

Related

ENSMUSP00000022078.6, ENSMUST00000022078.12

Conserved Domains (3) summary

smart00225
Location:421 → 518

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:413 → 515

BTB; BTB/POZ domain

cl21455
Location:34 → 174

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

76017656..76092054 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517411.5 → XP_006517474.1 rho-related BTB domain-containing protein 3 isoform X2

Conserved Domains (4) summary

cd18357
Location:236 → 393

BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18532
Location:471 → 553

BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cl38908
Location:410 → 461

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:34 → 174

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036158195.1 → XP_036014088.1 rho-related BTB domain-containing protein 3 isoform X5

Conserved Domains (3) summary

cd18357
Location:42 → 199

BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18360
Location:216 → 325

BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18532
Location:335 → 417

BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
XM_011244574.3 → XP_011242876.1 rho-related BTB domain-containing protein 3 isoform X4

Conserved Domains (3) summary

cd18357
Location:102 → 259

BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18360
Location:276 → 385

BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18532
Location:395 → 477

BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
XM_011244573.3 → XP_011242875.1 rho-related BTB domain-containing protein 3 isoform X3

Conserved Domains (3) summary

cd18357
Location:140 → 297

BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18360
Location:314 → 423

BTB2_POZ_RHOBTB3; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cd18532
Location:433 → 515

BACK_RHOBTB3; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)