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    Klf13 Kruppel-like transcription factor 13 [ Mus musculus (house mouse) ]

    Gene ID: 50794, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klf13provided by MGI
    Official Full Name
    Kruppel-like transcription factor 13provided by MGI
    Primary source
    MGI:MGI:1354948
    See related
    Ensembl:ENSMUSG00000052040 AllianceGenome:MGI:1354948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bteb3; FKLF2; NSLP1; FKLF-2; RFLAT1; RFLAT-1; 0610043C13Rik; 9430029L20Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation and negative regulation of erythrocyte differentiation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and neural retina. Orthologous to human KLF13 (KLF transcription factor 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 63.8), lung adult (RPKM 36.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klf13 in Genome Data Viewer
    Location:
    7 C; 7 34.58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63536099..63588663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (63886351..63938915, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39023 Neighboring gene uncharacterized protein C9orf85 homolog pseudogene Neighboring gene predicted gene, 32345 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71042066-71042379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71046389-71046617 Neighboring gene predicted gene 27252 Neighboring gene predicted gene, 53391 Neighboring gene RIKEN cDNA E030018B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E3721 Neighboring gene STARR-seq mESC enhancer starr_19020 Neighboring gene STARR-positive B cell enhancer ABC_E4930 Neighboring gene STARR-seq mESC enhancer starr_19022 Neighboring gene predicted gene, 39024 Neighboring gene predicted gene, 51514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis. Yang S, et al. Cell Rep, 2023 Apr 25. PMID 37029927
    2. Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. Zhou M, et al. J Immunol, 2007 May 1. PMID 17442931, Free PMC Article
    3. KLF13 influences multiple stages of both B and T cell development. Outram SV, et al. Cell Cycle, 2008 Jul 1. PMID 18604172
    4. The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests compensatory function of family member Krüppel-like factor 9 in the peri-implantation uterus. Heard ME, et al. Biol Reprod, 2012 Nov. PMID 22993382, Free PMC Article
    5. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis. Zeng N, et al. Int J Exp Pathol, 2023 Feb. PMID 36583453, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.
      Title: KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.
    2. KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
      Title: KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
    3. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
      Title: KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
    4. The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
      Title: The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
    5. the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.
      Title: A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
    6. Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice
      Title: A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
    7. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
      Title: Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
    8. The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.
      Title: KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
    9. Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.
      Title: Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
    10. KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.
      Title: KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 13
    Names
    BTE-binding protein 3
    C2-H2 zinc finger protein
    Kruppel-like factor 13
    RANTES factor of late activated T-lymphocytes 1
    basic transcription element-binding protein 3
    erythroid transcription factor FKLF-2
    transcription factor BTEB3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021366.3 → NP_067341.2  Krueppel-like factor 13

      See identical proteins and their annotated locations for NP_067341.2

      Status: VALIDATED

      Source sequence(s)
      AC127344, AC148977
      Consensus CDS
      CCDS21331.1
      UniProtKB/Swiss-Prot
      Q9ESX3, Q9JHF8, Q9JJZ6
      UniProtKB/TrEMBL
      Q3U2G6
      Related
      ENSMUSP00000067680.8, ENSMUST00000063694.10
      Conserved Domains (2) summary
      COG5048
      Location:163 → 253
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:170 → 192
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      63536099..63588663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJZ6.2 GenPept UniProtKB/Swiss-Prot:Q9JJZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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