Glipr1l1 GLI pathogenesis-related 1 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glipr1l1provided by MGI
Official Full Name: GLI pathogenesis-related 1 like 1provided by MGI
Primary source: MGI:MGI:1916536
See related: Ensembl:ENSMUSG00000020213 AllianceGenome:MGI:1916536
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700011E04Rik
Summary: Enables molecular adaptor activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization and protein localization involved in acrosome reaction. Acts upstream of or within binding activity of sperm to zona pellucida. Located in acrosomal vesicle and sperm head-tail coupling apparatus. Part of protein complex involved in cell-cell adhesion. Is active in outer acrosomal membrane. Orthologous to human GLIPR1L1 (GLIPR1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 20.5) See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 60.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (111896094..111914415)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (112060189..112078510)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zona pellucida binding assays indicate that GLIPR1L1 has a role in the binding of sperm to the zona pellucida surrounding the oocyte.
Title: Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization involved in acrosome reaction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in outer acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in sperm head-tail coupling apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GLIPR1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027018.1 → NP_081294.1 GLIPR1-like protein 1 precursor

See identical proteins and their annotated locations for NP_081294.1

Status: VALIDATED

Source sequence(s)

AK005860, BX635028

Consensus CDS

CCDS48691.1

UniProtKB/Swiss-Prot

Q9DAG6

Related

ENSMUSP00000073302.5, ENSMUST00000073617.5

Conserved Domains (1) summary

cd05385
Location:40 → 181

SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

111896094..111914415

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514047.4 → XP_006514110.1 GLIPR1-like protein 1 isoform X1

Conserved Domains (1) summary

cl00133
Location:40 → 147

CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family