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    Fra10ac1 FRA10A associated CGG repeat 1 [ Mus musculus (house mouse) ]

    Gene ID: 70567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fra10ac1provided by MGI
    Official Full Name
    FRA10A associated CGG repeat 1provided by MGI
    Primary source
    MGI:MGI:1917817
    See related
    Ensembl:ENSMUSG00000054237 AllianceGenome:MGI:1917817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730455O13Rik
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to human FRA10AC1 (FRA10A associated CGG repeat 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.1), CNS E14 (RPKM 7.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fra10ac1 in Genome Data Viewer
    Location:
    19 C2; 19 32.82 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38176925..38213078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38188477..38224630, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32440 Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime Neighboring gene predicted gene, 52398 Neighboring gene STARR-seq mESC enhancer starr_46076 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:38298641-38298824 Neighboring gene STARR-seq mESC enhancer starr_46077 Neighboring gene STARR-seq mESC enhancer starr_46079 Neighboring gene predicted gene, 32574 Neighboring gene predicted gene, 32491 Neighboring gene predicted gene, 32771 Neighboring gene leucine-rich repeat LGI family, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. Sarafidou T, et al. Genomics, 2004 Jul. PMID 15203205
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein FRA10AC1 homolog
    Names
    FRA10AC1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081075.2 → NP_001074544.1  protein FRA10AC1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001074544.1

      Status: VALIDATED

      Source sequence(s)
      AC112153
      Consensus CDS
      CCDS37972.1
      UniProtKB/Swiss-Prot
      F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
      Related
      ENSMUSP00000070534.6, ENSMUST00000067167.6
      Conserved Domains (1) summary
      pfam09725
      Location:104 → 216
      Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

    2. NM_027466.1 → NP_081742.1  protein FRA10AC1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112153, AK017666, BB669528
      Related
      ENSMUST00000238007.2
      Conserved Domains (1) summary
      pfam09725
      Location:104 → 208
      Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      38176925..38213078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527335.4 → XP_006527398.1  protein FRA10AC1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006527398.1

      UniProtKB/Swiss-Prot
      F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
      Conserved Domains (1) summary
      pfam09725
      Location:104 → 216
      Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

    2. XM_006527334.3 → XP_006527397.1  protein FRA10AC1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006527397.1

      UniProtKB/Swiss-Prot
      F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
      Conserved Domains (1) summary
      pfam09725
      Location:104 → 216
      Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

    3. XM_017318291.2 → XP_017173780.1  protein FRA10AC1 homolog isoform X1

      Conserved Domains (1) summary
      pfam09725
      Location:193 → 305
      Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BP78.3 GenPept UniProtKB/Swiss-Prot:Q8BP78

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