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    Ints12 integrator complex subunit 12 [ Mus musculus (house mouse) ]

    Gene ID: 71793, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ints12provided by MGI
    Official Full Name
    integrator complex subunit 12provided by MGI
    Primary source
    MGI:MGI:1919043
    See related
    Ensembl:ENSMUSG00000028016 AllianceGenome:MGI:1919043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phf22; int12; 1110020M19Rik; 2810027J24Rik; 4930529N21Rik; A230056J18Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and liver and biliary system. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), placenta adult (RPKM 4.7) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ints12 in Genome Data Viewer
    Location:
    3 G3; 3 61.56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132797616..132816749)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133091855..133110988)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene predicted gene, 23196 Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene TIP41, TOR signalling pathway regulator-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6130 Neighboring gene STARR-positive B cell enhancer ABC_E9573 Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    integrator complex subunit 12
    Names
    PHD finger protein 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027927.4NP_082203.1  integrator complex subunit 12

      See identical proteins and their annotated locations for NP_082203.1

      Status: VALIDATED

      Source sequence(s)
      AK003874, AK015941, BQ174479, BX521801, BY155830, BY273040
      Consensus CDS
      CCDS17848.1
      UniProtKB/Swiss-Prot
      Q3U2Q5, Q921U2, Q9D168
      Related
      ENSMUSP00000029650.9, ENSMUST00000029650.9
      Conserved Domains (1) summary
      cd15501
      Location:160211
      PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      132797616..132816749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)