Pdia2 protein disulfide isomerase associated 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdia2provided by MGI
Official Full Name: protein disulfide isomerase associated 2provided by MGI
Primary source: MGI:MGI:1916441
See related: Ensembl:ENSMUSG00000024184 AllianceGenome:MGI:1916441
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdip; Pdipl; 1810041F13Rik
Summary: Predicted to enable protein-disulfide reductase activity. Acts upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in lens; lens epithelium; lens fiber; lens vesicle; and lens vesicle epithelium. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 77.1), small intestine adult (RPKM 48.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.07 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26414973..26418108, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26195999..26199134, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rotavirus-protein disulfide isomerase interaction was demonstrated in vitro as well as inMA104 cells and intestinal villi from suckling mice.
Title: [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system].
Data show that diabetic mice had a worse postinfarction remodeling associated with an altered protein disulfide isomerase (PDI). redox state.
Title: Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase.
The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer.
Title: Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.
Elevated Pdi expression is cis regulated and is not linked to diabetes susceptibility.
Title: Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493389

RH44784 (e-PCR)
- UniSTS:28633

AI661267 (e-PCR)
- UniSTS:180981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	TAS Traceable Author Statement more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein disulfide-isomerase A2

Names: protein disulfide isomerase (pancreas) like; protein disulfide isomerase, pancreatic

NP_001074539.1

EC 5.3.4.1

XP_006524935.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081070.1 → NP_001074539.1 protein disulfide-isomerase A2 precursor

See identical proteins and their annotated locations for NP_001074539.1

Status: PROVISIONAL

Source sequence(s)

AC126438

Consensus CDS

CCDS37510.1

UniProtKB/Swiss-Prot

D3Z6P0, Q14AV9

Related

ENSMUSP00000035584.8, ENSMUST00000039113.14

Conserved Domains (5) summary

cd02961
Location:48 → 150

PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...

cd02981
Location:158 → 257

PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02982
Location:262 → 371

PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02995
Location:392 → 494

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

TIGR01130
Location:45 → 506

ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26414973..26418108 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524872.2 → XP_006524935.1 protein disulfide-isomerase A2 isoform X1

Conserved Domains (1) summary

TIGR01130
Location:45 → 467

ER_PDI_fam; protein disulfide isomerase, eukaryotic