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    Cabcoco1 ciliary associated calcium binding coiled-coil 1 [ Mus musculus (house mouse) ]

    Gene ID: 73287, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cabcoco1provided by MGI
    Official Full Name
    ciliary associated calcium binding coiled-coil 1provided by MGI
    Primary source
    MGI:MGI:1920537
    See related
    Ensembl:ENSMUSG00000019945 AllianceGenome:MGI:1920537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700040L02Rik
    Summary
    Enables calcium ion binding activity. Acts upstream of or within sperm flagellum assembly. Located in centrosome; cytoplasm; and sperm flagellum. Is expressed in male reproductive gland or organ; metanephros; and small intestine. Orthologous to human CABCOCO1 (ciliary associated calcium binding coiled-coil 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 5.1), kidney adult (RPKM 1.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cabcoco1 in Genome Data Viewer
    Location:
    10 B5.2; 10 35.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (68266786..68377751, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (68430956..68541921, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930545H06 gene Neighboring gene STARR-seq mESC enhancer starr_27040 Neighboring gene STARR-positive B cell enhancer mm9_chr10:67818877-67819178 Neighboring gene predicted gene, 32748 Neighboring gene STARR-positive B cell enhancer ABC_E10621 Neighboring gene STARR-seq mESC enhancer starr_27041 Neighboring gene predicted gene, 40683 Neighboring gene STARR-positive B cell enhancer ABC_E9130 Neighboring gene STARR-positive B cell enhancer ABC_E8344 Neighboring gene STARR-seq mESC enhancer starr_27042 Neighboring gene STARR-positive B cell enhancer ABC_E6870 Neighboring gene STARR-positive B cell enhancer ABC_E8938 Neighboring gene predicted gene, 32872 Neighboring gene STARR-seq mESC enhancer starr_27043 Neighboring gene enolase 2, gamma neuronal pseudogene Neighboring gene transmembrane protein 26 Neighboring gene STARR-seq mESC enhancer starr_27044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC189 affects sperm flagellum formation by interacting with CABCOCO1. Wang M, et al. Natl Sci Rev, 2023 Sep. PMID 37601242, Free PMC Article
    2. CABCOCO1, a novel coiled-coil protein With calcium-binding activity, is localized in the sperm flagellum. Kawashima A, et al. Mol Reprod Dev, 2016 Oct. PMID 26990073
    3. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary-associated calcium-binding coiled-coil protein 1
    Names
    uncharacterized protein C10orf107 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028491.1 → NP_082767.1  ciliary-associated calcium-binding coiled-coil protein 1

      See identical proteins and their annotated locations for NP_082767.1

      Status: VALIDATED

      Source sequence(s)
      AK029622
      Consensus CDS
      CCDS23905.1
      UniProtKB/TrEMBL
      A0A0R4J010
      Related
      ENSMUSP00000020103.3, ENSMUST00000020103.9
      Conserved Domains (1) summary
      pfam14769
      Location:93 → 188
      CLAMP; Flagellar C1a complex subunit C1a-32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      68266786..68377751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514216.4 → XP_006514279.1  ciliary-associated calcium-binding coiled-coil protein 1 isoform X1

      Conserved Domains (1) summary
      pfam14769
      Location:93 → 188
      CLAMP; Flagellar C1a complex subunit C1a-32
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDT7.2 GenPept UniProtKB/Swiss-Prot:Q8CDT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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