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    Igkv1-135 immunoglobulin kappa variable 1-135 [ Mus musculus (house mouse) ]

    Gene ID: 243420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igkv1-135provided by MGI
    Official Full Name
    immunoglobulin kappa variable 1-135provided by MGI
    Primary source
    MGI:MGI:3819952
    See related
    Ensembl:ENSMUSG00000096336 IMGT/GENE-DB:IGKV1-135; AllianceGenome:MGI:3819952
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bd2; Gm4964
    Summary
    Predicted to be involved in immune response. Predicted to be part of immunoglobulin complex. Orthologous to several human genes including IGKV2-24 (immunoglobulin kappa variable 2-24); IGKV2-30 (immunoglobulin kappa variable 2-30); and IGKV2D-24 (immunoglobulin kappa variable 2D-24 (non-functional)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Igkv1-135 in Genome Data Viewer
    Location:
    6 C1; 6 30.91 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67586729..67587492)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67609745..67610508)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene STARR-seq mESC enhancer starr_16187 Neighboring gene STARR-seq mESC enhancer starr_16188 Neighboring gene immunoglobulin kappa chain variable 1-136 Neighboring gene ribosomal protein L18A, pseudogene 2 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene immunoglobulin kappa chain complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monoclonal antibodies to HIV-1 p24 core protein include pairs which exhibit synergistic binding. Stevens PW, et al. Mol Immunol, 1993 Feb. PMID 8433704
    2. Light chain contribution to specificity in anti-DNA antibodies. Ibrahim SM, et al. J Immunol, 1995 Sep 15. PMID 7673735
    3. Different VL and VH germ-line genes are used to produce similar combining sites with specificity for alpha(1----6)dextrans. Akolkar PN, et al. J Immunol, 1987 Jun 15. PMID 2438345
    4. Improving scFv antibody expression levels in the plant cytosol. Schouten A, et al. FEBS Lett, 1997 Sep 29. PMID 9351003
    5. A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus. Schupp IW, et al. Immunogenetics, 1997. PMID 8995184

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Other Names

    • Ig kappa chain
    • IgG1/kappa antibody
    • immunoglobulin kappa chain variable 1-135
    • immunoglobulin light chain variable region
    • predictd gene, 243420

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005612.1 

      Range
      54765..55528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      67586729..67587492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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