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    Catsper2 cation channel, sperm associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 212670, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Catsper2provided by MGI
    Official Full Name
    cation channel, sperm associated 2provided by MGI
    Primary source
    MGI:MGI:2387404
    See related
    Ensembl:ENSMUSG00000033486 AllianceGenome:MGI:2387404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables voltage-gated calcium channel activity. Involved in calcium ion transport. Acts upstream of or within fertilization; flagellated sperm motility; and sperm capacitation. Located in sperm flagellum. Part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 30.8) and CNS E18 (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    See Catsper2 in Genome Data Viewer
    Location:
    2 E5; 2 60.38 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121222109..121245082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121391633..121414598, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene serine incorporator 4 Neighboring gene small EDRK-rich factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the promoter region of the murine Catsper2 gene. Contreras-Marciales ADP, et al. FEBS Open Bio, 2022 Dec. PMID 36345591, Free PMC Article
    2. Identical phenotypes of CatSper1 and CatSper2 null sperm. Carlson AE, et al. J Biol Chem, 2005 Sep 16. PMID 16036917
    3. CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir. Ho K, et al. Reprod Fertil Dev, 2009. PMID 19210926
    4. Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers. Bystroff C. Reprod Biol, 2018 Mar. PMID 29371110, Free PMC Article
    5. Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Quill TA, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657366, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the promoter region of the murine Catsper2 gene.
      Title: Characterization of the promoter region of the murine Catsper2 gene.
    2. Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.
      Title: Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.
    3. CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
      Title: CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir.
    4. Data show that there is a significant downregulation of CatSpers 2 following spinal cord injury.
      Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
    5. CatSper1 and CatSper2 null sperm show identical phenotypes in mice
      Title: Identical phenotypes of CatSper1 and CatSper2 null sperm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation channel sperm-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153075.3 → NP_694715.2  cation channel sperm-associated protein 2

      See identical proteins and their annotated locations for NP_694715.2

      Status: VALIDATED

      Source sequence(s)
      AL845466
      Consensus CDS
      CCDS38216.1
      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      UniProtKB/TrEMBL
      A0A0A0MQ85
      Related
      ENSMUSP00000037222.5, ENSMUST00000038073.5
      Conserved Domains (1) summary
      pfam00520
      Location:105 → 350
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121222109..121245082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499081.5 → XP_006499144.1  cation channel sperm-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499144.1

      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      UniProtKB/TrEMBL
      A0A0A0MQ85
      Conserved Domains (1) summary
      pfam00520
      Location:105 → 350
      Ion_trans; Ion transport protein

    2. XM_030249229.2 → XP_030105089.1  cation channel sperm-associated protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      Conserved Domains (1) summary
      pfam00520
      Location:105 → 262
      Ion_trans; Ion transport protein

    3. XM_030249227.2 → XP_030105087.1  cation channel sperm-associated protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      Conserved Domains (1) summary
      pfam00520
      Location:105 → 262
      Ion_trans; Ion transport protein

    4. XM_011239413.4 → XP_011237715.1  cation channel sperm-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237715.1

      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      UniProtKB/TrEMBL
      A0A0A0MQ85
      Conserved Domains (1) summary
      pfam00520
      Location:105 → 350
      Ion_trans; Ion transport protein

    5. XM_030249234.2 → XP_030105094.1  cation channel sperm-associated protein 2 isoform X7

      Conserved Domains (1) summary
      pfam00520
      Location:105 → 341
      Ion_trans; Ion transport protein

    6. XM_030249233.2 → XP_030105093.1  cation channel sperm-associated protein 2 isoform X6

      Conserved Domains (1) summary
      pfam00520
      Location:13 → 112
      Ion_trans; Ion transport protein

    7. XM_006499084.5 → XP_006499147.1  cation channel sperm-associated protein 2 isoform X5

    8. XM_006499082.5 → XP_006499145.1  cation channel sperm-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A2ARP9, A2RSK0, Q91ZP5
      Conserved Domains (1) summary
      pfam00520
      Location:51 → 296
      Ion_trans; Ion transport protein

    9. XM_036160226.1 → XP_036016119.1  cation channel sperm-associated protein 2 isoform X6

      Conserved Domains (1) summary
      pfam00520
      Location:13 → 112
      Ion_trans; Ion transport protein

    10. XM_017316898.3 → XP_017172387.1  cation channel sperm-associated protein 2 isoform X7

      Conserved Domains (1) summary
      pfam00520
      Location:105 → 341
      Ion_trans; Ion transport protein

    11. XM_011239414.4 → XP_011237716.1  cation channel sperm-associated protein 2 isoform X4

      Conserved Domains (1) summary
      pfam00520
      Location:105 → 350
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ARP9.2 GenPept UniProtKB/Swiss-Prot:A2ARP9

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