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    Slc14a2 solute carrier family 14 (urea transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 27411, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc14a2provided by MGI
    Official Full Name
    solute carrier family 14 (urea transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1351653
    See related
    Ensembl:ENSMUSG00000024552 AllianceGenome:MGI:1351653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UT-A1; UT-A3
    Summary
    Enables urea transmembrane transporter activity. Predicted to be involved in urea transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in metanephros and nervous system. Orthologous to human SLC14A2 (solute carrier family 14 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 38.3), testis adult (RPKM 8.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Slc14a2 in Genome Data Viewer
    Location:
    18 E3; 18 52.53 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (78189359..78640165, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (78146144..78596950, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45139 Neighboring gene sialic acid binding Ig-like lectin 15 Neighboring gene solute carrier family 14 (urea transporter), member 1 Neighboring gene predicted gene, 36338 Neighboring gene STARR-positive B cell enhancer mm9_chr18:78408899-78409200 Neighboring gene STARR-seq mESC enhancer starr_45142 Neighboring gene STARR-seq mESC enhancer starr_45143 Neighboring gene VISTA enhancer mm173 Neighboring gene predicted gene, 54027 Neighboring gene STARR-seq mESC enhancer starr_45144 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene RIKEN cDNA 4931439C15 gene Neighboring gene STARR-seq mESC enhancer starr_45145 Neighboring gene predicted gene, 26430 Neighboring gene STARR-seq mESC enhancer starr_45147 Neighboring gene predicted gene, 23895 Neighboring gene SET binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_45148 Neighboring gene STARR-seq mESC enhancer starr_45149 Neighboring gene STARR-positive B cell enhancer ABC_E1963 Neighboring gene STARR-seq mESC enhancer starr_45150 Neighboring gene STARR-seq mESC enhancer starr_45151 Neighboring gene STARR-positive B cell enhancer ABC_E7614

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Uchida S, et al. Mol Cell Biol, 2005 Aug. PMID 16055743, Free PMC Article
    2. Vasopressin regulation of the renal UT-A3 urea transporter. Stewart GS, et al. Am J Physiol Renal Physiol, 2009 Mar. PMID 19052101
    3. Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities. Jacob VA, et al. Kidney Int, 2008 Nov. PMID 18854850, Free PMC Article
    4. Acute regulation of mUT-A3 urea transporter expressed in a MDCK cell line. Stewart GS, et al. Am J Physiol Renal Physiol, 2007 Apr. PMID 17148784
    5. Gamble's "economy of water" revisited: studies in urea transporter knockout mice. Fenton RA, et al. Am J Physiol Renal Physiol, 2006 Jul. PMID 16478978

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Urea transporter UT-A1 as a novel drug target for hyponatremia.
      Title: Urea transporter UT-A1 as a novel drug target for hyponatremia.
    2. Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3.
      Title: Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3.
    3. Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
      Title: Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
    4. The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism.
      Title: The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism.
    5. Reduced UT-A1/A3 activity reduces the severity of renal fibrosis following unilateral ureteral obstruction.
      Title: UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction.
    6. In summary, loss of both UT-A1 and UT-A3 (but not UT-A3 alone) causes elevated medullary NO production and salt wasting
      Title: Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.
    7. Functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs.
      Title: Generation and phenotypic analysis of mice lacking all urea transporters.
    8. results suggest that GSK3 may in part modulate the hypertonic-induced intracellular UT-A1 redistribution and its accumulation on the plasma membrane, which may constitute another mechanism by which GSK3 modulates urine concentration
      Title: Glycogen Synthase Kinase-3 Modulates Hyperosmotic-Induced Urea Transporter A1 Relocation in the Inner Medullary Collecting Duct Cells.
    9. UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways.
      Title: Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.
    10. Studies indicate that urea transporter Slc14a2 (UT-A1/3) knockout mouse models showed the essential role of urea for producing maximally concentrated urine.
      Title: Urea transporter knockout mice and their renal phenotypes.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183591

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables urea transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables urea transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in urea transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    urea transporter 2
    Names
    solute carrier family 14 member 2
    urea transporter, kidney

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110273.2 → NP_001103743.1  urea transporter 2 isoform c

      See identical proteins and their annotated locations for NP_001103743.1

      Status: VALIDATED

      Source sequence(s)
      AC112792
      Consensus CDS
      CCDS89283.1
      UniProtKB/TrEMBL
      Q8BMD1
      Related
      ENSMUSP00000157855.2, ENSMUST00000237290.2
      Conserved Domains (1) summary
      pfam03253
      Location:58 → 353
      UT; Urea transporter

    2. NM_001110274.2 → NP_001103744.1  urea transporter 2 isoform d

      See identical proteins and their annotated locations for NP_001103744.1

      Status: VALIDATED

      Source sequence(s)
      AC112792
      Consensus CDS
      CCDS50331.1
      UniProtKB/TrEMBL
      A0A0R4J213
      Related
      ENSMUSP00000126416.2, ENSMUST00000163367.3
      Conserved Domains (1) summary
      pfam03253
      Location:1 → 274
      UT; Urea transporter

    3. NM_030683.4 → NP_109608.1  urea transporter 2 isoform b

      See identical proteins and their annotated locations for NP_109608.1

      Status: VALIDATED

      Source sequence(s)
      AC112792, AC140455, AC145554, AC151578
      Consensus CDS
      CCDS89284.1
      UniProtKB/TrEMBL
      A0A494BAL3
      Related
      ENSMUSP00000158141.2, ENSMUST00000235389.2
      Conserved Domains (1) summary
      pfam03253
      Location:128 → 412
      UT; Urea transporter

    4. NM_207651.4 → NP_997534.2  urea transporter 2 isoform a

      See identical proteins and their annotated locations for NP_997534.2

      Status: VALIDATED

      Source sequence(s)
      AC112792, AC140455, AC145554, AC151578
      Consensus CDS
      CCDS29361.1
      UniProtKB/Swiss-Prot
      B2RWS5, Q8K5D0, Q8R4T9, Q9ES04, Q9ES05
      UniProtKB/TrEMBL
      G5E849
      Related
      ENSMUSP00000157851.2, ENSMUST00000237674.2
      Conserved Domains (1) summary
      pfam03253
      Location:591 → 886
      UT; Urea transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      78189359..78640165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526488.1 → XP_006526551.1  urea transporter 2 isoform X1

      Conserved Domains (1) summary
      pfam03253
      Location:128 → 384
      UT; Urea transporter

    2. XM_017317915.1 → XP_017173404.1  urea transporter 2 isoform X2

      Conserved Domains (1) summary
      pfam03253
      Location:1 → 246
      UT; Urea transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4T9.2 GenPept UniProtKB/Swiss-Prot:Q8R4T9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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