Arid3b AT-rich interaction domain 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arid3bprovided by MGI
Official Full Name: AT-rich interaction domain 3Bprovided by MGI
Primary source: MGI:MGI:1930768
See related: Ensembl:ENSMUSG00000004661 AllianceGenome:MGI:1930768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bdp; Dri2
Summary: Predicted to enable DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human ARID3B (AT-rich interaction domain 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 15.4), testis adult (RPKM 14.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.56 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57697636..57744130, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57790353..57836847, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The different patterns of ARID3B in normal tissues translate into different roles for ARID3B in carcinomas.
Title: Differential expression of ARID3B in normal adult tissue and carcinomas.
Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn.
Title: Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn.
Arid3b is involved in the regulation of cell motility and rearrangements that lead to apical ectodermal ridge maturation.
Title: Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements.
ARID3B seems to play a key role in the malignant transformation of neuroblastoma and may serve as a marker of malignancy and also as a potential target for cancer therapy of stage IV neuroblastoma.
Title: ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma.
indispensable for production of cranial mesenchymal tissues
Title: Microarray analysis of PDGFR alpha+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 3B

Names: ARID domain-containing protein 3B; AT rich interactive domain 3B (BRIGHT-like); AT rich interactive domain 3B (Bright like); bright and dead ringer gene product homologous protein Bdp; bright and dead ringer protein; bright-like protein; dead ringer homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379353.1 → NP_001366282.1 AT-rich interactive domain-containing protein 3B isoform 1

Status: VALIDATED

Source sequence(s)

AC122534

UniProtKB/Swiss-Prot

Q3UTG1, Q810L9, Q9Z1N7

UniProtKB/TrEMBL

B2RWY2

Conserved Domains (1) summary

cd16879
Location:202 → 327

ARID_ARID3B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3B (ARID3B) and similar proteins
NM_001433913.1 → NP_001420842.1 AT-rich interactive domain-containing protein 3B isoform 2

Status: VALIDATED

Source sequence(s)

AC122534
NM_019689.3 → NP_062663.1 AT-rich interactive domain-containing protein 3B isoform 1

See identical proteins and their annotated locations for NP_062663.1

Status: VALIDATED

Source sequence(s)

AC122534

Consensus CDS

CCDS23233.1

UniProtKB/Swiss-Prot

Q3UTG1, Q810L9, Q9Z1N7

UniProtKB/TrEMBL

B2RWY2

Related

ENSMUSP00000130173.2, ENSMUST00000171444.8

Conserved Domains (1) summary

cd16879
Location:202 → 327

ARID_ARID3B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3B (ARID3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57697636..57744130 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244462.1 → XP_030100322.1 AT-rich interactive domain-containing protein 3B isoform X3

Conserved Domains (1) summary

cl28902
Location:1 → 88

ARID; ARID/BRIGHT DNA binding domain family
XM_011242774.1 → XP_011241076.1 AT-rich interactive domain-containing protein 3B isoform X2

Conserved Domains (1) summary

cl28902
Location:1 → 101

ARID; ARID/BRIGHT DNA binding domain family
XM_011242776.2 → XP_011241078.1 AT-rich interactive domain-containing protein 3B isoform X3

See identical proteins and their annotated locations for XP_011241078.1

Conserved Domains (1) summary

cl28902
Location:1 → 88

ARID; ARID/BRIGHT DNA binding domain family
XM_006511292.5 → XP_006511355.1 AT-rich interactive domain-containing protein 3B isoform X1

UniProtKB/TrEMBL

F8WIN2

Related

ENSMUSP00000096283.4, ENSMUST00000098686.4

Conserved Domains (1) summary

cd16879
Location:202 → 327

ARID_ARID3B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3B (ARID3B) and similar proteins