Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc27a1provided by MGI
Official Full Name: solute carrier family 27 (fatty acid transporter), member 1provided by MGI
Primary source: MGI:MGI:1347098
See related: Ensembl:ENSMUSG00000031808 AllianceGenome:MGI:1347098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fatp; FATP1; Vlc27a1
Summary: Enables several functions, including fatty acid-CoA ligase activity; identical protein binding activity; and protein serine/threonine kinase activator activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and positive regulation of triglyceride biosynthetic process. Acts upstream of or within several processes, including adiponectin-activated signaling pathway; fatty acid transport; and response to insulin. Located in basal plasma membrane and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; phalanx; and sensory organ. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in mammary gland adult (RPKM 230.7), adrenal adult (RPKM 183.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72021372..72039951)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71568728..71587307)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that FATP1 regulates the production of inflammatory cytokines through ceramide and the c-Jun N-terminal kinase signaling pathway
Title: Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling.
Macrophage Fatp1 limits atherogenesis in LDL receptor knockout mice.
Title: Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr(-/-) mice.
our results suggest that FATP1 localized at the basal membrane of brain microvessels contributes to the transport of docosahexaenoic acid, taurine and biotin into the brain
Title: The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport.
MicroRNA-199a targets FATP1 and inhibits the adipogenic transdifferentiation of cultured myoblasts.
Title: MicroRNA-199a Targets the Fatty Acid Transport Protein 1 Gene and Inhibits the Adipogenic Trans-Differentiation of C2C12 Myoblasts.
These results suggest that n-3 polyunsaturated fatty acids could improve lipid oxidation-related enzymes in liver subjected to hemorrhagic shock/resuscitation.
Title: N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor α Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation.
Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4 mutants, and FATP1 sorted to the same intracellular organelles as endogenous FATP4
Title: Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.
FATP1 was localized in mitochondria, in the outer membrane and intermembrane parts, of mouse skeletal muscle
Title: Fatty acid transport protein 1 (FATP1) localizes in mitochondria in mouse skeletal muscle and regulates lipid and ketone body disposal.
Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations.
Title: Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations.
microRNA-mediated silencing of TR4 in 3T3-L1 adipocytes drastically reduced basal FATP1 5' promoter activity and FATP1 expression with reduced lipid accumulation.
Title: TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes.
Overexpression of Fatp1 in skeletal muscle increased the rate of long-chain fatty acid transport and channelled these lipids to oxidation, not to intramuscular lipid accumulation.
Title: Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc27a1 (e-PCR), detects polymorphism
- UniSTS:507227

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB393209 (e-PCR)
- UniSTS:208298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables biotin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables biotin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oleoyl-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biotin import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in biotin import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in biotin transport	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose import in response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within medium-chain fatty acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of heat generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transport protein 1

Names: arachidonate--CoA ligase; fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; very long-chain acyl-CoA synthetase

NP_001344109.1

EC 6.2.1.15

EC 6.2.1.3

NP_001344110.1

EC 6.2.1.15

EC 6.2.1.3

NP_001344111.1

EC 6.2.1.15

EC 6.2.1.3

NP_036107.1

EC 6.2.1.15

EC 6.2.1.3

XP_006509734.1

EC 6.2.1.15

EC 6.2.1.3

XP_006509737.1

EC 6.2.1.15

EC 6.2.1.3

XP_006509738.1

EC 6.2.1.15

EC 6.2.1.3

XP_006509740.1

EC 6.2.1.15

EC 6.2.1.3

XP_006509741.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099434.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099436.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099438.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099439.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099440.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099441.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099442.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099443.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099445.1

EC 6.2.1.15

EC 6.2.1.3

XP_030099446.1

EC 6.2.1.15

EC 6.2.1.3

XP_036009949.1

EC 6.2.1.15

EC 6.2.1.3

XP_036009950.1

EC 6.2.1.15

EC 6.2.1.3

XP_036009951.1

EC 6.2.1.15

EC 6.2.1.3

XP_036009952.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357180.2 → NP_001344109.1 long-chain fatty acid transport protein 1

Status: VALIDATED

Source sequence(s)

AC162033

Consensus CDS

CCDS40386.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Related

ENSMUSP00000148768.2, ENSMUST00000212889.2

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
NM_001357181.2 → NP_001344110.1 long-chain fatty acid transport protein 1

Status: VALIDATED

Source sequence(s)

AC162033

Consensus CDS

CCDS40386.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
NM_001357182.2 → NP_001344111.1 long-chain fatty acid transport protein 1

Status: VALIDATED

Source sequence(s)

AC162033

Consensus CDS

CCDS40386.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
NM_011977.5 → NP_036107.1 long-chain fatty acid transport protein 1

See identical proteins and their annotated locations for NP_036107.1

Status: VALIDATED

Source sequence(s)

AC162033

Consensus CDS

CCDS40386.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Related

ENSMUSP00000034267.5, ENSMUST00000034267.5

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

72021372..72039951

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243582.1 → XP_030099442.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006509675.4 → XP_006509738.1 long-chain fatty acid transport protein 1 isoform X2

See identical proteins and their annotated locations for XP_006509738.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006509674.4 → XP_006509737.1 long-chain fatty acid transport protein 1 isoform X2

See identical proteins and their annotated locations for XP_006509737.1

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_036154057.1 → XP_036009950.1 long-chain fatty acid transport protein 1 isoform X1

UniProtKB/TrEMBL

Q3TP13

Conserved Domains (1) summary

cl17068
Location:115 → 622

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243580.2 → XP_030099440.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243579.2 → XP_030099439.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243574.2 → XP_030099434.1 long-chain fatty acid transport protein 1 isoform X1

UniProtKB/TrEMBL

Q3TP13

Conserved Domains (1) summary

cl17068
Location:115 → 622

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243578.2 → XP_030099438.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_036154058.1 → XP_036009951.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_036154056.1 → XP_036009949.1 long-chain fatty acid transport protein 1 isoform X1

UniProtKB/TrEMBL

Q3TP13

Conserved Domains (1) summary

cl17068
Location:115 → 622

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006509671.5 → XP_006509734.1 long-chain fatty acid transport protein 1 isoform X1

UniProtKB/TrEMBL

Q3TP13

Conserved Domains (1) summary

cl17068
Location:115 → 622

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243576.2 → XP_030099436.1 long-chain fatty acid transport protein 1 isoform X1

UniProtKB/TrEMBL

Q3TP13

Conserved Domains (1) summary

cl17068
Location:115 → 622

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243585.2 → XP_030099445.1 long-chain fatty acid transport protein 1 isoform X3

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243586.2 → XP_030099446.1 long-chain fatty acid transport protein 1 isoform X3

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_036154059.1 → XP_036009952.1 long-chain fatty acid transport protein 1 isoform X3

Related

ENSMUST00000212211.2

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006509678.5 → XP_006509741.1 long-chain fatty acid transport protein 1 isoform X3

See identical proteins and their annotated locations for XP_006509741.1

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006509677.2 → XP_006509740.1 long-chain fatty acid transport protein 1 isoform X3

See identical proteins and their annotated locations for XP_006509740.1

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243583.2 → XP_030099443.1 long-chain fatty acid transport protein 1 isoform X3

Conserved Domains (1) summary

cl17068
Location:33 → 427

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_030243581.2 → XP_030099441.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

Q60714

UniProtKB/TrEMBL

Q3TP13, Q544D7

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily