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    Dcaf8l DDB1 and CUL4 associated factor 8 like [ Mus musculus (house mouse) ]

    Gene ID: 18630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf8lprovided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 8 likeprovided by MGI
    Primary source
    MGI:MGI:101758
    See related
    Ensembl:ENSMUSG00000035395 AllianceGenome:MGI:101758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pet2; Pex3; PC231; PC326
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1) and DCAF8L2 (DDB1 and CUL4 associated factor 8 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Dcaf8l in Genome Data Viewer
    Location:
    X C1; X 39.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (88447454..88453295, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (89403848..89409689, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene melanoma antigen family A pseudogene Neighboring gene melanoma antigen family B, 16 pseudogene Neighboring gene predicted gene 14804 Neighboring gene eukaryotic translation initiation factor 4H pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence and expression of a murine cDNA encoding PC326, a novel gene expressed in plasmacytomas but not normal plasma cells. Bergsagel PL, et al. Oncogene, 1992 Oct. PMID 1408147
    2. Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells. Timblin C, et al. Nucleic Acids Res, 1990 Mar 25. PMID 2326198, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 8-like protein 2
    Names
    plasmacytoma expressed transcript 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008821.2 → NP_032847.2  DDB1- and CUL4-associated factor 8-like protein 2

      See identical proteins and their annotated locations for NP_032847.2

      Status: VALIDATED

      Source sequence(s)
      AL732291
      Consensus CDS
      CCDS30263.1
      UniProtKB/TrEMBL
      A2AHY8, Q01078
      Related
      ENSMUSP00000109593.3, ENSMUST00000113960.3
      Conserved Domains (2) summary
      sd00039
      Location:358 → 394
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:345 → 666
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      88447454..88453295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318426.2 → XP_017173915.1  DDB1- and CUL4-associated factor 8-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A2AHY8, Q01078
      Conserved Domains (2) summary
      sd00039
      Location:358 → 394
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:345 → 666
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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