Cisd1 CDGSH iron sulfur domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cisd1provided by MGI
Official Full Name: CDGSH iron sulfur domain 1provided by MGI
Primary source: MGI:MGI:1261855
See related: Ensembl:ENSMUSG00000037710 AllianceGenome:MGI:1261855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zcd1; mitoNEET; D10Ertd214e
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; L-cysteine transaminase activity; and protein homodimerization activity. Acts upstream of or within regulation of cellular respiration. Located in mitochondrial outer membrane. Is expressed in several structures, including ganglia; genitourinary system; heart; immune system; and liver. Orthologous to human CISD1 (CDGSH iron sulfur domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 115.7), liver adult (RPKM 78.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.88 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (71166324..71180679, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (71330494..71344849, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1.
Title: CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1.
Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure.
Title: Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure.
Study uncovered elevated presynaptic mitochondrial protein levels of mitoNEET in P42 compared to P7 mice. Overexpression of mitoNEET resulted in increased ATP production, elevated mitochondrial membrane potential, and a fragmented mitochondrial network with decreased mitochondrial biomass in cells of neuronal origin.
Title: Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development.
MitoNEET in perivascular adipose tissue prevents PVAT inflammation and is negatively associated with arterial stiffness in aging mice.
Title: MitoNEET in Perivascular Adipose Tissue Prevents Arterial Stiffness in Aging Mice.
mNEET plays a specific role in the formation of intermitochondrial junctions and thus participates in the adaptation of cells to physiological changes and to the control of mitochondrial homeostasis.
Title: MitoNEET-dependent formation of intermitochondrial junctions.
Together, these data suggest that mitoNEET KO mice exhibit many of the characteristics of early neurodegeneration in PD and may provide a novel drug discovery platform to evaluate compounds for enhancing mitochondrial function in neurodegenerative disorders.
Title: MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
mitoNEET protects intact cardiac cells from oxidative stress induced apoptosis during hypoxia and reoxygenation.
Title: MitoNEET Protects HL-1 Cardiomyocytes from Oxidative Stress Mediated Apoptosis in an In Vitro Model of Hypoxia and Reoxygenation.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
Title: MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
the mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic environment.
Title: MitoNEET-mediated effects on browning of white adipose tissue.
The MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.
Title: Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW011916 (e-PCR)
- UniSTS:165696

AU043990 (e-PCR)
- UniSTS:180050

RH126447 (e-PCR)
- UniSTS:163155

AW743335 (e-PCR)
- UniSTS:208755

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables L-cysteine transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-cysteine transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-cysteine transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic side of mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: CDGSH iron-sulfur domain-containing protein 1

Names: cysteine transaminase CISD1; zinc finger, CDGSH-type domain 1

NP_598768.1

EC 2.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134007.4 → NP_598768.1 CDGSH iron-sulfur domain-containing protein 1

See identical proteins and their annotated locations for NP_598768.1

Status: PROVISIONAL

Source sequence(s)

AC153509, AC156270

Consensus CDS

CCDS23917.1

UniProtKB/Swiss-Prot

Q3V2I3, Q8WUQ5, Q91WS0

Related

ENSMUSP00000043559.9, ENSMUST00000045887.9

Conserved Domains (2) summary

smart00704
Location:55 → 93

ZnF_CDGSH; CDGSH-type zinc finger. Function unknown

pfam10660
Location:12 → 41

MitoNEET_N; Iron-containing outer mitochondrial membrane protein N-terminus