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    Fdxr ferredoxin reductase [ Mus musculus (house mouse) ]

    Gene ID: 14149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fdxrprovided by MGI
    Official Full Name
    ferredoxin reductaseprovided by MGI
    Primary source
    MGI:MGI:104724
    See related
    Ensembl:ENSMUSG00000018861 AllianceGenome:MGI:104724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AR
    Summary
    Predicted to enable NADPH binding activity and NADPH-adrenodoxin reductase activity. Predicted to be involved in NADPH oxidation and steroid biosynthetic process. Located in mitochondrial inner membrane. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 647.4) and ovary adult (RPKM 88.8) See more
    Orthologs
    human all
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    Genomic context

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    See Fdxr in Genome Data Viewer
    Location:
    11 E2; 11 80.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115158850..115167925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115268024..115277101, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:115048516-115048817 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115088135-115088322 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115088428-115088537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115092913-115093101 Neighboring gene glutamate receptor, ionotropic, NMDA2C (epsilon 3) Neighboring gene STARR-positive B cell enhancer ABC_E44 Neighboring gene fatty acid desaturase domain family, member 6 Neighboring gene otopetrin 2 Neighboring gene USH1 protein network component sans

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced form of sheep ferredoxin reductase. Furukawa A, et al. Biol Reprod, 1997 May. PMID 9160736
    2. Ferredoxin 1 is essential for embryonic development and lipid homeostasis. Mohibi S, et al. Elife, 2024 Jan 22. PMID 38251655, Free PMC Article
    3. Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway. Zhang Y, et al. Oncogene, 2022 Mar. PMID 35121827, Free PMC Article
    4. Systemic Delivery of AAV-Fdxr Mitigates the Phenotypes of Mitochondrial Disorders in Fdxr Mutant Mice. Yang L, et al. Mol Ther Methods Clin Dev, 2020 Sep 11. PMID 32995353, Free PMC Article
    5. Integrated analysis of the molecular pathogenesis of FDXR-associated disease. Slone JD, et al. Cell Death Dis, 2020 Jun 4. PMID 32499495, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
      Title: hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
    2. Integrated analysis of the molecular pathogenesis of FDXR-associated disease.
      Title: Integrated analysis of the molecular pathogenesis of FDXR-associated disease.
    3. FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
      Title: FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.
    4. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment.
      Title: Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.
    5. FDXR and p53 are mutually regulated and that the FDXR-p53 loop is critical for tumor suppression via iron homeostasis.
      Title: Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH-adrenodoxin reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH-adrenodoxin reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH-adrenodoxin reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADPH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADPH:adrenodoxin oxidoreductase, mitochondrial
    Names
    adrenodoxin reductase
    ferredoxin--NADP(+) reductase
    NP_032023.1
    XP_006532249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430980.1 → NP_001417909.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603828
      UniProtKB/TrEMBL
      Q6IQY0

    2. NM_007997.2 → NP_032023.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_032023.1

      Status: VALIDATED

      Source sequence(s)
      AL603828
      Consensus CDS
      CCDS25625.1
      UniProtKB/Swiss-Prot
      Q61578
      UniProtKB/TrEMBL
      Q6IQY0
      Related
      ENSMUSP00000021078.3, ENSMUST00000021078.3
      Conserved Domains (2) summary
      PLN02852
      Location:10 → 490
      PLN02852; ferredoxin-NADP+ reductase
      cl21454
      Location:42 → 73
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115158850..115167925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532186.5 → XP_006532249.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl30539
      Location:10 → 472
      PLN02852; ferredoxin-NADP+ reductase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61578.1 GenPept UniProtKB/Swiss-Prot:Q61578

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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