ANXA2 annexin A2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANXA2provided by HGNC
Official Full Name: annexin A2provided by HGNC
Primary source: HGNC:HGNC:537
See related: Ensembl:ENSG00000182718 MIM:151740; AllianceGenome:HGNC:537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]
Expression: Ubiquitous expression in esophagus (RPKM 162.2), skin (RPKM 128.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (60347151..60397986, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (58149151..58201124, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (60639350..60690185, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2.
Title: The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2.
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2.
Title: PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2.
Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis.
Title: Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis.
Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane-Membrane Interfaces.
Title: Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane-Membrane Interfaces.
Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein.
Title: Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein.
FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.
Title: FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma.
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
Title: Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling.
Title: Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling.
ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.
Title: ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.
Title: FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.

Submit: New GeneRIF Correction See all GeneRIFs (416)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5	PubMed
Envelope transmembrane glycoprotein gp41	env	Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5	PubMed
Nef	nef	HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells	PubMed
Pr55(Gag)	gag	Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages	PubMed
	gag	Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag	PubMed
Tat	tat	In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH15753 (e-PCR)
- UniSTS:91710

SHGC-67307 (e-PCR)
- UniSTS:89991

PMC152906P1 (e-PCR)
- UniSTS:271244

RH66139 (e-PCR)
- UniSTS:91065

GDB:626485 (e-PCR)
- UniSTS:158398

D15S1185 (e-PCR)
- UniSTS:39361

D15S1292 (e-PCR)
- UniSTS:732

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables S100 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding involved in cell-cell adhesion	HDA more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of low-density lipoprotein particle receptor binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of low-density lipoprotein receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasma membrane repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in vesicle budding from membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PCSK9-AnxA2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PCSK9-AnxA2 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
located_in Schmidt-Lanterman incisure	IEA Inferred from Electronic Annotation more info
located_in adherens junction	HDA more info	PubMed
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
colocalizes_with membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath adaxonal region	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of plasma membrane protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in vesicle	HDA more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A2

Names: annexin II; annexin-2; calpactin I heavy chain; calpactin I heavy polypeptide; calpactin-1 heavy chain; chromobindin 8; epididymis secretory protein Li 270; epididymis secretory sperm binding protein; lipocortin II; placental anticoagulant protein IV; protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002857.2 → NP_001002857.1 annexin A2 isoform 2

See identical proteins and their annotated locations for NP_001002857.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AW087150, BC015834, BC023990

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8

UniProtKB/TrEMBL

A0A024R5Z7, V9HW65

Related

ENSP00000411352.2, ENST00000421017.6

Conserved Domains (1) summary

pfam00191
Location:109 → 174

Annexin
NM_001002858.3 → NP_001002858.1 annexin A2 isoform 1

See identical proteins and their annotated locations for NP_001002858.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA661718, AC087385, BC001388, BX640598

Consensus CDS

CCDS32256.1

UniProtKB/TrEMBL

V9HW65

Related

ENSP00000346032.3, ENST00000332680.8

Conserved Domains (1) summary

pfam00191
Location:127 → 192

Annexin; Annexin
NM_001136015.3 → NP_001129487.1 annexin A2 isoform 2

See identical proteins and their annotated locations for NP_001129487.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AA661718, BC093056

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8

UniProtKB/TrEMBL

A0A024R5Z7, V9HW65

Related

ENSP00000379342.3, ENST00000396024.7

Conserved Domains (1) summary

pfam00191
Location:109 → 174

Annexin
NM_004039.3 → NP_004030.1 annexin A2 isoform 2

See identical proteins and their annotated locations for NP_004030.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AW087150, BC015834, D00017

Consensus CDS

CCDS10175.1

UniProtKB/Swiss-Prot

P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8

UniProtKB/TrEMBL

A0A024R5Z7, V9HW65

Related

ENSP00000387545.3, ENST00000451270.7

Conserved Domains (1) summary

pfam00191
Location:109 → 174

Annexin