CNTN6 contactin 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNTN6provided by HGNC
Official Full Name: contactin 6provided by HGNC
Primary source: HGNC:HGNC:2176
See related: Ensembl:ENSG00000134115 MIM:607220; AllianceGenome:HGNC:2176
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NB3
Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Biased expression in thyroid (RPKM 3.8), lung (RPKM 1.4) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p26.3

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (1093024..1404217)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (870677..1398549)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (1134708..1445901)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch Signaling.
Title: Contactin 6, A Novel Causative Gene for Congenital Hypothyroidism, Mediates Thyroid Hormone Biosynthesis Through Notch Signaling.
CNTN6 copy number variations: Uncertain clinical significance in individuals with neurodevelopmental disorders.
Title: CNTN6 copy number variations: Uncertain clinical significance in individuals with neurodevelopmental disorders.
this study describes of 2 boys with intellectual disability, attention-deficit hyperactivity disorder harboring a 3p26.3 microdeletion and a 3p26.3 microduplication, which are both paternally inherited and include only the CNTN6 gene.
Title: Clinical and Molecular Characterization of Two Patients with CNTN6 Copy Number Variations.
Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway.
Title: CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.
CNTN6 copy number variants (duplications) were associated with increased risk of Tourette syndrome.
Title: Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer
Title: Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2022-09-28) ClinGen Genome Curation PagePubMed Haploinsufficency No evidence available (Last evaluated 2022-09-28) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association of lipid-lowering response to statins in combined study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S1307 (e-PCR), detects polymorphism
- UniSTS:40452

SHGC-82415 (e-PCR)
- UniSTS:170245

G16593 (e-PCR)
- UniSTS:59400

SHGC-83427 (e-PCR)
- UniSTS:101925

SHGC-111832 (e-PCR)
- UniSTS:168773

SHGC-111269 (e-PCR)
- UniSTS:168264

STS-N30615 (e-PCR)
- UniSTS:68455

G63331 (e-PCR)
- UniSTS:140444

RH119809 (e-PCR)
- UniSTS:133284

D3S1307 (e-PCR), detects polymorphism
- UniSTS:60328

SHGC-78040 (e-PCR)
- UniSTS:101571

SHGC-84547 (e-PCR)
- UniSTS:102885

RH44311 (e-PCR)
- UniSTS:19174

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in parallel fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: contactin-6

Names: neural adhesion molecule; neural recognition molecule NB-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047144.1 RefSeqGene

Range

89890..401083

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001289080.2 → NP_001276009.1 contactin-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_001276009.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 4-9 all encode the same isoform (1).

Source sequence(s)

AB003592, AC026214, AC034192, BC113118, CN364480, DB170583

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Related

ENSP00000407822.2, ENST00000446702.7

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001289081.2 → NP_001276010.1 contactin-6 isoform 2

See identical proteins and their annotated locations for NP_001276010.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC026214, AC034192, AK294786, BC113118, CN364480, DA094373

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (5) summary

cd04969
Location:352 → 424

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:434 → 522

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:336 → 424

I-set; Immunoglobulin I-set domain

cl11960
Location:247 → 331

Ig; Immunoglobulin domain
NM_001349350.2 → NP_001336279.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 1, 2, and 5-9, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349351.2 → NP_001336280.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6-9, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349352.2 → NP_001336281.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1, 2, 4, 5, and 7-9, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349353.2 → NP_001336282.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 1, 2, 4-6, 8 and 9, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349354.2 → NP_001336283.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 1, 2, 4-7, and 9, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349355.2 → NP_001336284.1 contactin-6 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 1, 2, and 4-8, encodes isoform 1.

Source sequence(s)

AC026214, AC027123, AC034192

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
NM_001349356.2 → NP_001336285.1 contactin-6 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (10) encodes isoform 3.

Source sequence(s)

AC026214, AC027123, AC034192

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:562 → 655

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:283 → 367

Ig; Immunoglobulin domain
NM_001349357.2 → NP_001336286.1 contactin-6 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (11) encodes isoform 4.

Source sequence(s)

AC026214, AC027123, AC034192

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:494 → 587

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:215 → 299

Ig; Immunoglobulin domain
NM_001349358.2 → NP_001336287.1 contactin-6 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (12) encodes isoform 5.

Source sequence(s)

AC026214, AC027123, AC034192

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (3) summary

smart00060
Location:718 → 798

FN3; Fibronectin type 3 domain

cd00063
Location:413 → 506

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:330 → 413

Ig; Immunoglobulin domain
NM_001349359.2 → NP_001336288.1 contactin-6 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 14-16, encodes isoform 6.

Source sequence(s)

AC026214, AC027123, AC034192

Conserved Domains (3) summary

smart00060
Location:529 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:224 → 317

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:141 → 224

Ig; Immunoglobulin domain
NM_001349360.2 → NP_001336289.1 contactin-6 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 13, 15, and 16, encodes isoform 6.

Source sequence(s)

AC026214, AC027123, AC034192

Conserved Domains (3) summary

smart00060
Location:529 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:224 → 317

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:141 → 224

Ig; Immunoglobulin domain
NM_001349361.2 → NP_001336290.1 contactin-6 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 13, 14, and 16, encodes isoform 6.

Source sequence(s)

AC026214, AC027123, AC034192

Conserved Domains (3) summary

smart00060
Location:529 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:224 → 317

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:141 → 224

Ig; Immunoglobulin domain
NM_001349362.2 → NP_001336291.1 contactin-6 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variants 13-15, encodes isoform 6.

Source sequence(s)

AC026214, AC027123, AC034192

Conserved Domains (3) summary

smart00060
Location:529 → 609

FN3; Fibronectin type 3 domain

cd00063
Location:224 → 317

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:141 → 224

Ig; Immunoglobulin domain
NM_014461.4 → NP_055276.1 contactin-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_055276.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2, and 4-9 all encode the same isoform (1).

Source sequence(s)

AB003592, AC026214, AC034192, BC036338, CN364480

Consensus CDS

CCDS2557.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Related

ENSP00000341882.2, ENST00000350110.2

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

1093024..1404217

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011533590.3 → XP_011531892.1 contactin-6 isoform X1

See identical proteins and their annotated locations for XP_011531892.1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
XM_047447972.1 → XP_047303928.1 contactin-6 isoform X1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52
XM_047447974.1 → XP_047303930.1 contactin-6 isoform X4
XM_017006177.3 → XP_016861666.1 contactin-6 isoform X3
XM_017006172.3 → XP_016861661.1 contactin-6 isoform X1

UniProtKB/Swiss-Prot

Q2KHM2, Q9UQ52

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (2) summary

cd00063
Location:598 → 691

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:319 → 403

Ig; Immunoglobulin domain
XM_011533591.4 → XP_011531893.1 contactin-6 isoform X2

See identical proteins and their annotated locations for XP_011531893.1

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (5) summary

cd04969
Location:352 → 424

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:434 → 522

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:336 → 424

I-set; Immunoglobulin I-set domain

cl11960
Location:247 → 331

Ig; Immunoglobulin domain
XM_017006174.2 → XP_016861663.1 contactin-6 isoform X2

UniProtKB/TrEMBL

B4DGV0

Conserved Domains (5) summary

cd04969
Location:352 → 424

Ig5_Contactin_like; Fifth Ig domain of contactin

smart00410
Location:434 → 522

IG_like; Immunoglobulin like

cd00063
Location:526 → 619

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:336 → 424

I-set; Immunoglobulin I-set domain

cl11960
Location:247 → 331

Ig; Immunoglobulin domain