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    MGST2 microsomal glutathione S-transferase 2 [ Homo sapiens (human) ]

    Gene ID: 4258, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MGST2provided by HGNC
    Official Full Name
    microsomal glutathione S-transferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7063
    See related
    Ensembl:ENSG00000085871 MIM:601733; AllianceGenome:HGNC:7063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST2; MGST-II
    Summary
    The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MGST2 in Genome Data Viewer
    Location:
    4q31.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (139665819..139754618)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (142985421..143074258)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (140586973..140661899)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377622 Neighboring gene Sharpr-MPRA regulatory region 6908 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:140586532-140587731 Neighboring gene QKI interacting lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21930 Neighboring gene RN7SK pseudogene 237 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:140632274-140633473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:140661600-140662100 Neighboring gene H3 histone pseudogene 16 Neighboring gene uncharacterized LOC124900781 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene uncharacterized LOC124900782

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. Yan KL, et al. J Invest Dermatol, 2006 May. PMID 16498398
    2. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. Yang S, et al. Arch Dermatol Res, 2006 Aug. PMID 16773312
    3. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. Thulasingam M, et al. Nat Commun, 2021 Mar 19. PMID 33741927, Free PMC Article
    4. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. Jakobsson PJ, et al. J Lipid Mediat Cell Signal, 1997 Sep. PMID 9302651
    5. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Sjöström M, et al. Eur J Biochem, 2001 May. PMID 11322876

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
      Title: Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
    2. Trimeric microsomal protein MGST2 displays one third of the sites reactivity.
      Title: Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
    3. characterized the substrate specificity and catalytic properties of purified MGST2 by steady-state and pre-steady-state kinetic experiments
      Title: Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
    6. A large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the psoriasis susceptibility gene within the PSORS9 locus.
      Title: Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27438, MGC14097

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C4 synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microsomal glutathione S-transferase 2
    Names
    glutathione peroxidase MGST2
    leukotriene C4 synthase MGST2
    microsomal GST-2
    microsomal GST-II
    microsomal glutathione S-transferase II
    NP_001191295.1
    NP_001191296.1
    NP_001191297.1
    NP_002404.1
    XP_016863700.1
    XP_016863701.1
    XP_016863702.1
    XP_047271657.1
    XP_054206024.1
    XP_054206025.1
    XP_054206026.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204366.2 → NP_001191295.1  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001191295.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' UTR and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS3749.1
      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000482639.1, ENST00000616265.4
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 111
      MAPEG; MAPEG family

    2. NM_001204367.2 → NP_001191296.1  microsomal glutathione S-transferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001191296.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an alternate 3' UTR, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC108053, AC112236
      Related
      ENST00000515137.5

    3. NM_001204368.2 → NP_001191297.1  microsomal glutathione S-transferase 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001191297.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS56339.1
      UniProtKB/Swiss-Prot
      Q99735
      Related
      ENSP00000424278.1, ENST00000506797.5

    4. NM_002413.5 → NP_002404.1  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_002404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is a predominant transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC108053, AC112236
      Consensus CDS
      CCDS3749.1
      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000265498.1, ENST00000265498.6
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 111
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      139665819..139754618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008211.3 → XP_016863700.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 111
      MAPEG; MAPEG family

    2. XM_047415701.1 → XP_047271657.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735

    3. XM_017008212.3 → XP_016863701.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Related
      ENSP00000423008.1, ENST00000503816.1
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 111
      MAPEG; MAPEG family

    4. XM_017008213.2 → XP_016863702.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 111
      MAPEG; MAPEG family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      142985421..143074258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350049.1 → XP_054206024.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735

    2. XM_054350050.1 → XP_054206025.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735

    3. XM_054350051.1 → XP_054206026.1  microsomal glutathione S-transferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D6RBB5, Q7Z5B8, Q99735
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99735.1 GenPept UniProtKB/Swiss-Prot:Q99735

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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