Krt36 keratin 36 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt36provided by RGD
Official Full Name: keratin 36provided by RGD
Primary source: RGD:1305792
See related: EnsemblRapid:ENSRNOG00000031805 AllianceGenome:RGD:1305792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ka31; Krt1-5
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in epithelial cell differentiation; intermediate filament organization; and regulation of keratinocyte differentiation. Predicted to be located in keratin filament. Predicted to be active in intermediate filament cytoskeleton. Orthologous to human KRT36 (keratin 36). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 3.2), Muscle (RPKM 1.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85536779..85540403, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85036379..85040003, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88016602..88019967, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type I cuticular Ha6

Names: keratin 36, type I; keratin complex 1, acidic, gene 5; type I hair keratin KA31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008759.2 → NP_001008759.1 keratin, type I cuticular Ha6

See identical proteins and their annotated locations for NP_001008759.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F1LNF9, Q6IFV5

Related

ENSRNOP00000046297.3, ENSRNOT00000047580.5

Conserved Domains (2) summary

pfam00038
Location:87 → 398

Filament; Intermediate filament protein

cl23720
Location:241 → 381

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)