Baz2a bromodomain adjacent to zinc finger domain, 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Baz2aprovided by RGD
Official Full Name: bromodomain adjacent to zinc finger domain, 2Aprovided by RGD
Primary source: RGD:1305037
See related: EnsemblRapid:ENSRNOG00000053881 AllianceGenome:RGD:1305037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin-protein adaptor activity; lysine-acetylated histone binding activity; and nucleic acid binding activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase I. Predicted to act upstream of or within rDNA heterochromatin formation. Predicted to be located in cytosol; nuclear lumen; and rDNA heterochromatin. Predicted to be part of NoRC complex and chromatin silencing complex. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 186.9), Adrenal (RPKM 150.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1107377..1145507)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (523204..560911)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2518267..2548840)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH124269 (e-PCR)
- UniSTS:161091

BI291455 (e-PCR)
- UniSTS:244636

RH69868 (e-PCR)
- UniSTS:15021

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase I core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rDNA heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in rDNA heterochromatin formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NoRC complex	ISO Inferred from Sequence Orthology more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in rDNA heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in rDNA heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain adjacent to zinc finger domain protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107158.2 → NP_001100628.2 bromodomain adjacent to zinc finger domain protein 2A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K178

Related

ENSRNOP00000098645.1, ENSRNOT00000126073.1

Conserved Domains (8) summary

cd05503
Location:1792 → 1888

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:836 → 898

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:407 → 514

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1115 → 1397

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:541 → 613

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1669 → 1715

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1430 → 1464

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:292 → 513

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1107377..1145507

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078958.2 → XP_038934886.1 bromodomain adjacent to zinc finger domain protein 2A isoform X1

UniProtKB/TrEMBL

A0A0G2K178

Conserved Domains (8) summary

cd05503
Location:1802 → 1898

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:838 → 900

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:409 → 516

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1117 → 1399

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:543 → 615

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1679 → 1725

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1440 → 1474

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:294 → 515

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_063263394.1 → XP_063119464.1 bromodomain adjacent to zinc finger domain protein 2A isoform X1

UniProtKB/TrEMBL

A0A0G2K178
XM_039078959.2 → XP_038934887.1 bromodomain adjacent to zinc finger domain protein 2A isoform X2

UniProtKB/TrEMBL

A0A0G2K178

Conserved Domains (8) summary

cd05503
Location:1801 → 1897

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:838 → 900

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:409 → 516

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1117 → 1399

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:543 → 615

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1679 → 1725

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1440 → 1474

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:294 → 515

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_039078960.2 → XP_038934888.1 bromodomain adjacent to zinc finger domain protein 2A isoform X3

UniProtKB/TrEMBL

A0A0G2K178

Related

ENSRNOP00000089740.2, ENSRNOT00000107364.2

Conserved Domains (8) summary

cd05503
Location:1794 → 1890

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:838 → 900

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:409 → 516

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1117 → 1399

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:543 → 615

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1671 → 1717

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1432 → 1466

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:294 → 515

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_063263395.1 → XP_063119465.1 bromodomain adjacent to zinc finger domain protein 2A isoform X4

UniProtKB/TrEMBL

A0A0G2K178, A0A8I6A7X6
XM_039078962.2 → XP_038934890.1 bromodomain adjacent to zinc finger domain protein 2A isoform X5

UniProtKB/TrEMBL

A0A0G2K178, A0A8I5ZP85

Conserved Domains (8) summary

cd05503
Location:1800 → 1896

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:836 → 898

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:407 → 514

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1115 → 1397

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:541 → 613

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1677 → 1723

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1438 → 1472

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:292 → 513

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_039078965.2 → XP_038934893.1 bromodomain adjacent to zinc finger domain protein 2A isoform X5

UniProtKB/TrEMBL

A0A0G2K178, A0A8I5ZP85

Conserved Domains (8) summary

cd05503
Location:1800 → 1896

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:836 → 898

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:407 → 514

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1115 → 1397

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:541 → 613

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1677 → 1723

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1438 → 1472

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:292 → 513

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_039078966.2 → XP_038934894.1 bromodomain adjacent to zinc finger domain protein 2A isoform X5

UniProtKB/TrEMBL

A0A0G2K178, A0A8I5ZP85

Conserved Domains (8) summary

cd05503
Location:1800 → 1896

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:836 → 898

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:407 → 514

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1115 → 1397

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:541 → 613

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1677 → 1723

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1438 → 1472

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:292 → 513

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_039078961.2 → XP_038934889.1 bromodomain adjacent to zinc finger domain protein 2A isoform X5

UniProtKB/TrEMBL

A0A0G2K178, A0A8I5ZP85

Related

ENSRNOP00000079756.1, ENSRNOT00000111243.2

Conserved Domains (8) summary

cd05503
Location:1800 → 1896

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:836 → 898

DDT; domain in different transcription and chromosome remodeling factors

PRK07003
Location:407 → 514

PRK07003; DNA polymerase III subunit gamma/tau

PRK10263
Location:1115 → 1397

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:541 → 613

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1677 → 1723

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15613
Location:1438 → 1472

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033913
Location:292 → 513

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_063263396.1 → XP_063119466.1 bromodomain adjacent to zinc finger domain protein 2A isoform X5

UniProtKB/TrEMBL

A0A0G2K178, A0A8I5ZP85
XM_039078968.2 → XP_038934896.1 bromodomain adjacent to zinc finger domain protein 2A isoform X6

Conserved Domains (7) summary

cd05503
Location:1260 → 1356

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00571
Location:296 → 358

DDT; domain in different transcription and chromosome remodeling factors

PRK10263
Location:575 → 864

PRK10263; DNA translocase FtsK; Provisional

cd01397
Location:10 → 73

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15629
Location:1137 → 1183

PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)

pfam15822
Location:737 → 822

MISS; MAPK-interacting and spindle-stabilizing protein-like

pfam15613
Location:898 → 932

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif