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    Camp cathelicidin antimicrobial peptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316010, updated on 27-Nov-2024

    Summary

    Official Symbol
    Campprovided by RGD
    Official Full Name
    cathelicidin antimicrobial peptideprovided by RGD
    Primary source
    RGD:1559878
    See related
    EnsemblRapid:ENSRNOG00000020733 AllianceGenome:RGD:1559878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CRAMP
    Summary
    Predicted to enable lipopolysaccharide binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of angiogenesis; and response to bacterium. Located in cell projection and extracellular space. Orthologous to human CAMP (cathelicidin antimicrobial peptide). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 289.5) and Thymus (RPKM 42.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Camp in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118720184..118721998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109841729..109843543, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117930557..117932371, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene cell division cycle 25A Neighboring gene microtubule-associated protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptidoglycan IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytolysis by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cathelicidin antimicrobial peptide
    Names
    cathelin-related antimicrobial peptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100724.1NP_001094194.1  cathelicidin antimicrobial peptide precursor

      See identical proteins and their annotated locations for NP_001094194.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3C7, G3V8S9, Q71KM5
      Related
      ENSRNOP00000028130.4, ENSRNOT00000028130.9
      Conserved Domains (2) summary
      pfam00666
      Location:3197
      Cathelicidins; Cathelicidin
      pfam12153
      Location:142167
      CAP18_C; LPS binding domain of CAP18 (C terminal)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118720184..118721998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)