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    Ubqln3 ubiquilin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubqln3provided by RGD
    Official Full Name
    ubiquilin 3provided by RGD
    Primary source
    RGD:1304920
    See related
    EnsemblRapid:ENSRNOG00000023833 AllianceGenome:RGD:1304920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human UBQLN3 (ubiquilin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 510.9) See more
    Orthologs
    human all
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    Genomic context

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    See Ubqln3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (168016508..168019201, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158604629..158607318, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (169331457..169334120, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485159 Neighboring gene ubiquilin 5 Neighboring gene ubiquilin-like Neighboring gene olfactomedin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquilin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107543.2 → NP_001101013.1  ubiquilin-3

      See identical proteins and their annotated locations for NP_001101013.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161885
      UniProtKB/TrEMBL
      B1WBT8
      Conserved Domains (4) summary
      smart00727
      Location:189 → 233
      STI1; Heat shock chaperonin-binding motif
      smart00213
      Location:22 → 92
      UBQ; Ubiquitin homologues
      cd14399
      Location:615 → 652
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cl00155
      Location:22 → 92
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      168016508..168019201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262967.1 → XP_063119037.1  ubiquilin-3 isoform X3

    2. XM_039078150.2 → XP_038934078.1  ubiquilin-3 isoform X2

      Conserved Domains (2) summary
      cd01808
      Location:43 → 115
      Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cl17974
      Location:218 → 258
      STI1; STI1 domain

    3. XM_017589198.2 → XP_017444687.1  ubiquilin-3 isoform X1

      UniProtKB/TrEMBL
      F7EYK8
      Related
      ENSRNOP00000034011.5, ENSRNOT00000032587.6
    Nucleotide Protein Strain
    Heading Accession and Version

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