Swap70 switching B-cell complex subunit SWAP70 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Swap70provided by RGD
Official Full Name: switching B-cell complex subunit SWAP70provided by RGD
Primary source: RGD:1305579
See related: EnsemblRapid:ENSRNOG00000009910 AllianceGenome:RGD:1305579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity and DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Predicted to act upstream of or within isotype switching. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be active in cytoplasm; nucleus; and postsynapse. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 403.2), Kidney (RPKM 129.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (173702338..173763540)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164267588..164328796)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (174862683..174924101)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1Rat54 (e-PCR)
- UniSTS:118595

RH138692 (e-PCR)
- UniSTS:220779

D1Rat420 (e-PCR), detects polymorphism
- UniSTS:227204

D1Rat425 (e-PCR), detects polymorphism
- UniSTS:227209

RH134218 (e-PCR)
- UniSTS:217500

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within isotype switching	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic cell DNA recombination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: switch-associated protein 70

Names: SWA-70 protein; SWAP complex protein; SWAP switching B-cell complex 70; SWAP-70 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106288.1 → NP_001099758.1 switch-associated protein 70

See identical proteins and their annotated locations for NP_001099758.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I811, D3ZRE7

Related

ENSRNOP00000104275.1, ENSRNOT00000141310.1

Conserved Domains (2) summary

cd13273
Location:204 → 313

PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain

TIGR02168
Location:332 → 549

SMC_prok_B; chromosome segregation protein SMC, common bacterial type