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    Pwwp2a PWWP domain containing 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pwwp2aprovided by RGD
    Official Full Name
    PWWP domain containing 2Aprovided by RGD
    Primary source
    RGD:1305891
    See related
    EnsemblRapid:ENSRNOG00000003936 AllianceGenome:RGD:1305891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305891
    Summary
    Predicted to enable NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of transcriptional start site selection at RNA polymerase II promoter. Predicted to be active in nucleus. Orthologous to human PWWP2A (PWWP domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 114.1), Lung (RPKM 80.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pwwp2a in Genome Data Viewer
    Location:
    10q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28654272..28696693)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28155509..28195255)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29288060..29335425)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase inhibitory factor subunit 1, pseudogene 2 Neighboring gene ribosomal protein S2, pseudogene 35 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene uncharacterized LOC108352076 Neighboring gene adrenoceptor alpha 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis. Su L, et al. Acta Biochim Pol, 2023 Sep 6. PMID 37672715
    2. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. Pünzeler S, et al. EMBO J, 2017 Aug 1. PMID 28645917, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
      Title: Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NuRD complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PWWP domain-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127296.2 → NP_001120768.1  PWWP domain-containing protein 2A isoform 2

      See identical proteins and their annotated locations for NP_001120768.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      B2RYP9
      Related
      ENSRNOP00000060940.1, ENSRNOT00000067013.3

    2. NM_001414339.1 → NP_001401268.1  PWWP domain-containing protein 2A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZT71
      Related
      ENSRNOP00000080500.1, ENSRNOT00000097586.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      28654272..28696693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085909.2 → XP_038941837.1  PWWP domain-containing protein 2A isoform X3

    2. XM_039085908.2 → XP_038941836.1  PWWP domain-containing protein 2A isoform X3

    3. XM_006246139.5 → XP_006246201.1  PWWP domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I6GK76

    4. XM_039085901.2 → XP_038941829.1  PWWP domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      cd05835
      Location:431 → 517
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    5. XM_039085900.2 → XP_038941828.1  PWWP domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      cd05835
      Location:431 → 517
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    6. XM_063268965.1 → XP_063125035.1  PWWP domain-containing protein 2A isoform X1

    7. XM_039085902.2 → XP_038941830.1  PWWP domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      cd05835
      Location:431 → 517
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    8. XM_039085904.2 → XP_038941832.1  PWWP domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      cd05835
      Location:431 → 517
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    9. XM_039085905.2 → XP_038941833.1  PWWP domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      cd05835
      Location:431 → 517
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

    10. XM_063268966.1 → XP_063125036.1  PWWP domain-containing protein 2A isoform X1

    RNA

    1. XR_010055175.1 RNA Sequence

    2. XR_010055176.1 RNA Sequence

    3. XR_005489805.2 RNA Sequence

    4. XR_010055177.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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