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    Epb41l2 erythrocyte membrane protein band 4.1-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epb41l2provided by RGD
    Official Full Name
    erythrocyte membrane protein band 4.1-like 2provided by RGD
    Primary source
    RGD:1563977
    See related
    EnsemblRapid:ENSRNOG00000012346 AllianceGenome:RGD:1563977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1l2; RGD1563977
    Summary
    Predicted to enable PH domain binding activity and spectrin binding activity. Predicted to be involved in actomyosin structure organization and positive regulation of protein localization to cell cortex. Predicted to be located in cell cortex; cell junction; and nucleoplasm. Predicted to be part of COP9 signalosome. Predicted to be active in cytoskeleton and plasma membrane. Orthologous to human EPB41L2 (erythrocyte membrane protein band 4.1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 186.7), Testes (RPKM 104.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epb41l2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (21682336..21857106, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (19863010..20037795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (20881820..21067713, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 9 Neighboring gene uncharacterized LOC134482583 Neighboring gene small leucine-rich protein 1 Neighboring gene uncharacterized LOC102552728 Neighboring gene cyclin B2, pseudogene 2 Neighboring gene A-kinase anchoring protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 4.1G promotes arborization and tight junction formation of oligodendrocyte cell line OLN-93. Xia W, et al. J Cell Physiol, 2012 Jun. PMID 21898413
    2. Cytoskeletal protein 4.1G is a binding partner of the metabotropic glutamate receptor subtype 1 alpha. Lu D, et al. J Neurosci Res, 2004 Oct 1. PMID 15372499
    3. Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action. Lu D, et al. Biochem J, 2004 Jan 1. PMID 12974671, Free PMC Article
    4. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. Kontrogianni-Konstantopoulos A, et al. J Biol Chem, 2001 Jun 8. PMID 11274145
    5. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Kiyomitsu T, et al. Cell, 2013 Jul 18. PMID 23870127, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest functional roles of 4.1G/Epb4.112 in cellular arborization and tight junction formation in oligodendrocytes.
      Title: 4.1G promotes arborization and tight junction formation of oligodendrocyte cell line OLN-93.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400827.1 → NP_001387756.1  band 4.1-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KU05, D3ZDT1
      Related
      ENSRNOP00000017322.5, ENSRNOT00000017322.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      21682336..21857106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099066.2 → XP_038954994.1  band 4.1-like protein 2 isoform X1

      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:959 → 1064
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    2. XM_039099143.2 → XP_038955071.1  band 4.1-like protein 2 isoform X27

      UniProtKB/TrEMBL
      D3ZAY2
      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:604 → 691
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    3. XM_039099134.2 → XP_038955062.1  band 4.1-like protein 2 isoform X25

      UniProtKB/TrEMBL
      D3ZAY7
      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:706 → 795
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    4. XM_039099128.2 → XP_038955056.1  band 4.1-like protein 2 isoform X24

      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:731 → 836
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    5. XM_063265513.1 → XP_063121583.1  band 4.1-like protein 2 isoform X21

    6. XM_063265508.1 → XP_063121578.1  band 4.1-like protein 2 isoform X20

    7. XM_039099123.2 → XP_038955051.1  band 4.1-like protein 2 isoform X16

      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:844 → 949
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    8. XM_039099119.2 → XP_038955047.1  band 4.1-like protein 2 isoform X14

      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:863 → 968
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    9. XM_063265458.1 → XP_063121528.1  band 4.1-like protein 2 isoform X12

    10. XM_063265521.1 → XP_063121591.1  band 4.1-like protein 2 isoform X23

    11. XM_063265473.1 → XP_063121543.1  band 4.1-like protein 2 isoform X18

    12. XM_063265461.1 → XP_063121531.1  band 4.1-like protein 2 isoform X13

    13. XM_063265514.1 → XP_063121584.1  band 4.1-like protein 2 isoform X22

    14. XM_063265422.1 → XP_063121492.1  band 4.1-like protein 2 isoform X2

      Related
      ENSRNOP00000101515.1, ENSRNOT00000166148.1

    15. XM_063265468.1 → XP_063121538.1  band 4.1-like protein 2 isoform X15

    16. XM_039099113.2 → XP_038955041.1  band 4.1-like protein 2 isoform X10

      UniProtKB/TrEMBL
      A6KU04, D3ZM69
      Related
      ENSRNOP00000058049.3, ENSRNOT00000061332.7
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:884 → 989
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    17. XM_039099103.2 → XP_038955031.1  band 4.1-like protein 2 isoform X8

      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:903 → 1008
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    18. XM_063265470.1 → XP_063121540.1  band 4.1-like protein 2 isoform X17

    19. XM_063265452.1 → XP_063121522.1  band 4.1-like protein 2 isoform X11

    20. XM_063265433.1 → XP_063121503.1  band 4.1-like protein 2 isoform X6

    21. XM_063265431.1 → XP_063121501.1  band 4.1-like protein 2 isoform X5

    22. XM_039099094.2 → XP_038955022.1  band 4.1-like protein 2 isoform X7

      Related
      ENSRNOP00000104039.1, ENSRNOT00000149297.1
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:914 → 1019
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    23. XM_063265440.1 → XP_063121510.1  band 4.1-like protein 2 isoform X9

    24. XM_039099083.2 → XP_038955011.1  band 4.1-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K162
      Related
      ENSRNOP00000103905.1, ENSRNOT00000166769.1
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:933 → 1038
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    25. XM_039099076.2 → XP_038955004.1  band 4.1-like protein 2 isoform X3

      Related
      ENSRNOP00000071713.3, ENSRNOT00000079688.3
      Conserved Domains (6) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:622 → 662
      SAB; SAB domain
      pfam05902
      Location:936 → 1041
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    26. XM_063265477.1 → XP_063121547.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    27. XM_063265386.1 → XP_063121456.1  band 4.1-like protein 2 isoform X1

    28. XM_063265430.1 → XP_063121500.1  band 4.1-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K162

    29. XM_063265551.1 → XP_063121621.1  band 4.1-like protein 2 isoform X27

      UniProtKB/TrEMBL
      D3ZAY2
      Related
      ENSRNOP00000017417.5, ENSRNOT00000017417.7

    30. XM_017589862.3 → XP_017445351.1  band 4.1-like protein 2 isoform X25

      UniProtKB/TrEMBL
      D3ZAY7
      Related
      ENSRNOP00000017412.5, ENSRNOT00000017412.8
      Conserved Domains (5) summary
      PTZ00121
      Location:4 → 216
      PTZ00121; MAEBL; Provisional
      smart00295
      Location:215 → 404
      B41; Band 4.1 homologues
      cd13184
      Location:399 → 492
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:706 → 795
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:502 → 545
      FA; FERM adjacent (FA)

    31. XM_063265444.1 → XP_063121514.1  band 4.1-like protein 2 isoform X10

      UniProtKB/TrEMBL
      A6KU04, D3ZM69

    32. XM_063265492.1 → XP_063121562.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    33. XM_063265547.1 → XP_063121617.1  band 4.1-like protein 2 isoform X27

      UniProtKB/TrEMBL
      D3ZAY2

    34. XM_063265540.1 → XP_063121610.1  band 4.1-like protein 2 isoform X26

    35. XM_063265490.1 → XP_063121560.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    36. XM_063265395.1 → XP_063121465.1  band 4.1-like protein 2 isoform X1

    37. XM_063265376.1 → XP_063121446.1  band 4.1-like protein 2 isoform X1

    38. XM_063265545.1 → XP_063121615.1  band 4.1-like protein 2 isoform X27

      UniProtKB/TrEMBL
      D3ZAY2

    39. XM_063265480.1 → XP_063121550.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    40. XM_063265475.1 → XP_063121545.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    41. XM_063265451.1 → XP_063121521.1  band 4.1-like protein 2 isoform X10

      UniProtKB/TrEMBL
      A6KU04, D3ZM69

    42. XM_063265495.1 → XP_063121565.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    43. XM_063265483.1 → XP_063121553.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    44. XM_063265403.1 → XP_063121473.1  band 4.1-like protein 2 isoform X1

    45. XM_063265418.1 → XP_063121488.1  band 4.1-like protein 2 isoform X1

    46. XM_063265501.1 → XP_063121571.1  band 4.1-like protein 2 isoform X19

      UniProtKB/TrEMBL
      A6KU05, D3ZDT1

    47. XM_063265410.1 → XP_063121480.1  band 4.1-like protein 2 isoform X1

    48. XM_063265449.1 → XP_063121519.1  band 4.1-like protein 2 isoform X10

      UniProtKB/TrEMBL
      A6KU04, D3ZM69

    49. XM_063265510.1 → XP_063121580.1  band 4.1-like protein 2 isoform X20

    Nucleotide Protein Strain
    Heading Accession and Version

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