Arhgap15 Rho GTPase activating protein 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap15provided by RGD
Official Full Name: Rho GTPase activating protein 15provided by RGD
Primary source: RGD:1359304
See related: EnsemblRapid:ENSRNOG00000031168 AllianceGenome:RGD:1359304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within regulation of cell shape. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARHGAP15 (Rho GTPase activating protein 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 448.6), Spleen (RPKM 362.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (48382945..49002213)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (27989368..28592722)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (28626987..29236225)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048503 (e-PCR)
- UniSTS:144953

AU049602 (e-PCR)
- UniSTS:146048

RH138477 (e-PCR)
- UniSTS:220564

D3Chm57 (e-PCR)
- UniSTS:265379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 15

Names: rho GTPase-activating protein 15-like; rho-type GTPase-activating protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013917.1 → NP_001013939.1 rho GTPase-activating protein 15 isoform 1

See identical proteins and their annotated locations for NP_001013939.1

Status: PROVISIONAL

Source sequence(s)

BC079103

UniProtKB/Swiss-Prot

Q6AYC5

UniProtKB/TrEMBL

A0A8I6AHH5

Related

ENSRNOP00000099545.1, ENSRNOT00000128189.1

Conserved Domains (3) summary

cd04403
Location:286 → 472

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:89 → 199

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:88 → 197

PH; PH domain
NM_001429793.1 → NP_001416722.1 rho GTPase-activating protein 15 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZW94