Eloa elongin A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eloaprovided by RGD
Official Full Name: elongin Aprovided by RGD
Primary source: RGD:3827
See related: EnsemblRapid:ENSRNOG00000010902 AllianceGenome:RGD:3827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: El; Tceb3
Summary: Predicted to enable double-stranded DNA binding activity. Involved in regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Located in site of DNA damage. Part of transcription elongation factor complex. Orthologous to several human genes including ELOA (elongin A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 209.0), Adrenal (RPKM 199.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153513246..153530819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148231600..148246760, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154348167..154363324, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
Title: Transcriptional properties of mammalian elongin A and its role in stress response.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of elongin complex	IEA Inferred from Electronic Annotation more info
part_of elongin complex	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed
part_of transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elongin-A

Names: RNA polymerase II transcription factor SIII subunit A; RNA polymerase II transcription factor SIII subunit A1; RNA polymerase II transcription factor elongin subunit A (110 kDa); SIII p110; elongin 110 kDa subunit; transcription elongation factor B (SIII), polypeptide 3; transcription elongation factor B polypeptide 3; transcription elongation factor B subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017103.2 → NP_058799.2 elongin-A

See identical proteins and their annotated locations for NP_058799.2

Status: PROVISIONAL

Source sequence(s)

BC081815

UniProtKB/Swiss-Prot

Q63187

UniProtKB/TrEMBL

Q66HK4

Related

ENSRNOP00000097263.2, ENSRNOT00000101125.2

Conserved Domains (2) summary

cd00183
Location:37 → 76

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

pfam06881
Location:565 → 663

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A