Clock clock circadian regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Clockprovided by RGD
Official Full Name: clock circadian regulatorprovided by RGD
Primary source: RGD:620271
See related: EnsemblRapid:ENSRNOG00000002175 AllianceGenome:RGD:620271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Expression: Biased expression in Kidney (RPKM 160.4), Heart (RPKM 145.8) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (32262747..32346872)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (31908542..31992673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (34418226..34502218)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression.
Title: Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression.
Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats.
Title: Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats.
rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.
Title: rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression.
The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells.
Title: The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells.
Rhythmic Regulation of DNA Methylation Factors and Core-Clock Genes in Brain Structures Activated by Cocaine or Sucrose: Potential Role of Chromatin Remodeling.
Title: Rhythmic Regulation of DNA Methylation Factors and Core-Clock Genes in Brain Structures Activated by Cocaine or Sucrose: Potential Role of Chromatin Remodeling.
Social defeat stress affects resident's clock gene and bdnf expression in the brain.
Title: Social defeat stress affects resident's clock gene and bdnf expression in the brain.
The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia-ischemia brain injury.
Title: The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia-ischemia brain injury.
Circadian variability of clock genes, except Cry1, was present in the normal esophagus and was completely disrupted in reflux esophagitis during the acute phase. The circadian variability of Per2, Per3, and Arntl returned to normal, but disruption of Per1, Cry2, and Clock was present in the chronic phase.
Title: Changes in Clock Genes Expression in Esophagus in Rat Reflux Esophagitis.
Clock mRNA expression in the hypoxic-ischemic brain damage (HIBD) group increased at 0 hour after HIBD, decreased at 48 hours after HIBD and increased at 72 hours after HIBD (P<0.05).
Title: [Expression profiles of miRNA-182 and Clock mRNA in the pineal gland of neonatal rats with hypoxic-ischemic brain damage].
A phase advance in rhythmic clock gene expression in the heart and kidney of diabetic rats.
Title: Effect of streptozotocin-induced diabetes on clock gene expression in tissues inside and outside the blood-brain barrier in rat.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Markers

D14S292 (e-PCR), detects polymorphism
- UniSTS:39460

RH137478 (e-PCR)
- UniSTS:219566

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in entrainment of circadian clock	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hair cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of hair cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
involved_in regulation of type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in regulation of type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to redox state	IEA Inferred from Electronic Annotation more info
involved_in response to redox state	ISO Inferred from Sequence Orthology more info
involved_in response to redox state	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CLOCK-BMAL transcription complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CLOCK-BMAL transcription complex	IEA Inferred from Electronic Annotation more info
part_of CLOCK-BMAL transcription complex	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	IEA Inferred from Electronic Annotation more info
located_in chromatoid body	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perichromatin fibrils	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: circadian locomoter output cycles protein kaput

Names: circadian locomoter output cycles kaput; rCLOCK

NP_001276761.2

EC 2.3.1.48

NP_001376183.1

EC 2.3.1.48

NP_068628.2

EC 2.3.1.48

XP_017454850.1

EC 2.3.1.48

XP_017454852.1

EC 2.3.1.48

XP_017454853.1

EC 2.3.1.48

XP_038948299.1

EC 2.3.1.48

XP_038948300.1

EC 2.3.1.48

XP_038948301.1

EC 2.3.1.48

XP_038948302.1

EC 2.3.1.48

XP_038948303.1

EC 2.3.1.48

XP_038948304.1

EC 2.3.1.48

XP_038948305.1

EC 2.3.1.48

XP_038948306.1

EC 2.3.1.48

XP_038948307.1

EC 2.3.1.48

XP_038948308.1

EC 2.3.1.48

XP_038948310.1

EC 2.3.1.48

XP_038948311.1

EC 2.3.1.48

XP_038948313.1

EC 2.3.1.48

XP_038948315.1

EC 2.3.1.48

XP_063129625.1

EC 2.3.1.48

XP_063129626.1

EC 2.3.1.48

XP_063129627.1

EC 2.3.1.48

XP_063129628.1

EC 2.3.1.48

XP_063129629.1

EC 2.3.1.48

XP_063129630.1

EC 2.3.1.48

XP_063129632.1

EC 2.3.1.48

XP_063129633.1

EC 2.3.1.48

XP_063129634.1

EC 2.3.1.48

XP_063129635.1

EC 2.3.1.48

XP_063129637.1

EC 2.3.1.48

XP_063129638.1

EC 2.3.1.48

XP_063129639.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289832.2 → NP_001276761.2 circadian locomoter output cycles protein kaput isoform S

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (S) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY8

Related

ENSRNOP00000002981.4, ENSRNOT00000002981.5

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
NM_001389254.1 → NP_001376183.1 circadian locomoter output cycles protein kaput isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Related

ENSRNOP00000074670.2, ENSRNOT00000085991.3

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
NM_021856.3 → NP_068628.2 circadian locomoter output cycles protein kaput isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY7

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

32262747..32346872

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273557.1 → XP_063129627.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_039092380.2 → XP_038948308.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092373.2 → XP_038948301.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092379.2 → XP_038948307.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_017599364.3 → XP_017454853.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273558.1 → XP_063129628.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_017599363.3 → XP_017454852.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273556.1 → XP_063129626.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_063273563.1 → XP_063129633.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_039092376.2 → XP_038948304.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092375.2 → XP_038948303.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_017599361.3 → XP_017454850.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273562.1 → XP_063129632.1 circadian locomoter output cycles protein kaput isoform X2

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY7
XM_063273568.1 → XP_063129638.1 circadian locomoter output cycles protein kaput isoform X4

UniProtKB/TrEMBL

D4A4R8
XM_063273569.1 → XP_063129639.1 circadian locomoter output cycles protein kaput isoform X5

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY8
XM_063273567.1 → XP_063129637.1 circadian locomoter output cycles protein kaput isoform X3

UniProtKB/TrEMBL

D4A4R8
XM_039092377.2 → XP_038948305.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092383.2 → XP_038948311.1 circadian locomoter output cycles protein kaput isoform X2

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY7

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092385.2 → XP_038948313.1 circadian locomoter output cycles protein kaput isoform X4

UniProtKB/TrEMBL

D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273560.1 → XP_063129630.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_063273564.1 → XP_063129634.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_063273555.1 → XP_063129625.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_039092374.2 → XP_038948302.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273559.1 → XP_063129629.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8
XM_039092372.2 → XP_038948300.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092371.2 → XP_038948299.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_063273565.1 → XP_063129635.1 circadian locomoter output cycles protein kaput isoform X2

UniProtKB/Swiss-Prot

Q920Y1, Q9WVS9

UniProtKB/TrEMBL

A6JCY7
XM_039092378.1 → XP_038948306.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092382.2 → XP_038948310.1 circadian locomoter output cycles protein kaput isoform X1

UniProtKB/TrEMBL

A0A0G2K8N0, D4A4R8

Conserved Domains (3) summary

cd19734
Location:29 → 89

bHLH-PAS_CLOCK; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins

pfam00989
Location:109 → 202

PAS; PAS fold

pfam14598
Location:274 → 377

PAS_11; PAS domain
XM_039092387.1 → XP_038948315.1 circadian locomoter output cycles protein kaput isoform X6

UniProtKB/TrEMBL

D4A4R8

Conserved Domains (2) summary

pfam00989
Location:3 → 77

PAS; PAS fold

pfam14598
Location:149 → 252

PAS_11; PAS domain