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    Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313507, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tal1provided by RGD
    Official Full Name
    TAL bHLH transcription factor 1, erythroid differentiation factorprovided by RGD
    Primary source
    RGD:1306748
    See related
    EnsemblRapid:ENSRNOG00000025051 AllianceGenome:RGD:1306748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tal-1
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to contribute to DNA binding activity. Predicted to be involved in several processes, including basophil differentiation; positive regulation of cellular component organization; and regulation of DNA-templated transcription. Predicted to act upstream of with a positive effect on transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 222.3), Lung (RPKM 66.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tal1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (133823093..133837737)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (128586776..128600976)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (133864401..133878604)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene STIL, centriolar assembly protein Neighboring gene uncharacterized LOC120102952 Neighboring gene PDZK1 interacting protein 1 Neighboring gene transfer RNA proline (anticodon AGG) 66

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within astrocyte fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basophil differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within generation of neurons ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemangioblast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spinal cord association neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_positive_effect transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell acute lymphocytic leukemia protein 1
    Names
    T-cell acute lymphocytic leukemia 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107958.2NP_001101428.2  T-cell acute lymphocytic leukemia protein 1

      See identical proteins and their annotated locations for NP_001101428.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      133823093..133837737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238618.5XP_006238680.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006238680.1

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    2. XM_006238615.5XP_006238677.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006238677.1

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    3. XM_063287732.1XP_063143802.1  T-cell acute lymphocytic leukemia protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1M1
      Related
      ENSRNOP00000034958.6, ENSRNOT00000035409.7
    4. XM_039109984.2XP_038965912.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    5. XM_039109985.2XP_038965913.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    6. XM_008763967.3XP_008762189.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008762189.1

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    7. XM_006238617.3XP_006238679.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006238679.1

      UniProtKB/TrEMBL
      D3Z921
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    8. XM_039109986.1XP_038965914.1  T-cell acute lymphocytic leukemia protein 1 isoform X2

      UniProtKB/TrEMBL
      D3Z921
      Related
      ENSRNOP00000071897.3, ENSRNOT00000091977.3
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins