Wars1 tryptophanyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wars1provided by RGD
Official Full Name: tryptophanyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1308278
See related: EnsemblRapid:ENSRNOG00000004359 AllianceGenome:RGD:1308278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wars
Summary: Predicted to enable several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; regulation of angiogenesis; and tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 100.1), Brain (RPKM 74.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (133540463..133571645, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (127776088..127807273, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (132771026..132802262, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

RH140754 (e-PCR)
- UniSTS:222820

RH128353 (e-PCR)
- UniSTS:211661

RH137812 (e-PCR)
- UniSTS:219899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tryptophan-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables tryptophan-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in tryptophanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tryptophanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tryptophan--tRNA ligase, cytoplasmic

Names: trpRS; tryptophanyl-tRNA synthetase, cytoplasmic

NP_001013188.2

EC 6.1.1.2

XP_038968331.1

EC 6.1.1.2

XP_038968332.1

EC 6.1.1.2

XP_063118081.1

EC 6.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013170.2 → NP_001013188.2 tryptophan--tRNA ligase, cytoplasmic

Status: VALIDATED

Source sequence(s)

AY724504

UniProtKB/TrEMBL

A6KBI0

Related

ENSRNOP00000049063.3, ENSRNOT00000050350.7

Conserved Domains (3) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

TIGR00233
Location:158 → 467

trpS; tryptophanyl-tRNA synthetase

pfam00458
Location:16 → 68

WHEP-TRS; WHEP-TRS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

133540463..133571645 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112404.2 → XP_038968332.1 tryptophan--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A6KBI0, F8WFH8

Conserved Domains (2) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

cd00936
Location:16 → 65

WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
XM_039112403.2 → XP_038968331.1 tryptophan--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A6KBI0, F8WFH8

Conserved Domains (2) summary

PLN02486
Location:89 → 470

PLN02486; aminoacyl-tRNA ligase

cd00936
Location:16 → 65

WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
XM_063262011.1 → XP_063118081.1 tryptophan--tRNA ligase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A6KBI0

Related

ENSRNOP00000073702.1, ENSRNOT00000080163.3