RT1-A3 RT1 class I, locus A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: RT1-A3provided by RGD
Official Full Name: RT1 class I, locus A3provided by RGD
Primary source: RGD:1359610
See related: EnsemblRapid:ENSRNOG00000071249 AllianceGenome:RGD:1359610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RT1; RT1-A; RT1.A3; RT1-A3n
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Genomic context

Location:: 20p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4849410..4853233)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4847518..4851344)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of the MHCI antigen processing and presentation pathway in hippocampal neurons and glia may contribute to age-related hippocampal dysfunction by increasing neuroimmune signaling or altering synaptic homeostasis.
Title: Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.

Submit: New GeneRIF Correction

General gene information

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Markers

H2-K1 (e-PCR), detects polymorphism
- UniSTS:463411

H2-Q6 (e-PCR), detects polymorphism
- UniSTS:143310

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: RT1 class I, locus A3

Names: MHC class I antigen; MHC class I protein; RT1 class I, A3; RT1 class Ia, A3n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008830.2 → NP_001008830.1 RT1 class I, locus A3 precursor

See identical proteins and their annotated locations for NP_001008830.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

Q9JHM2

Related

ENSRNOP00000098209.2, ENSRNOT00000120568.2

Conserved Domains (3) summary

cd07698
Location:204 → 296

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:343 → 368

MHC_I_C; MHC_I C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4849410..4853233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098676.2 → XP_038954604.1 RT1 class I, locus A3 isoform X1

Conserved Domains (3) summary

pfam00129
Location:22 → 200

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cd00096
Location:205 → 213

Ig; Ig strand A [structural motif]

cl11960
Location:202 → 296

Ig; Immunoglobulin domain