Cd247 Cd247 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd247provided by RGD
Official Full Name: Cd247 moleculeprovided by RGD
Primary source: RGD:2305
See related: EnsemblRapid:ENSRNOG00000003298 AllianceGenome:RGD:2305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd3z; TCRzeta
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Involved in cell surface receptor signaling pathway. Part of T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 929.3), Spleen (RPKM 119.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (80576264..80651422)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (78043302..78118437)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (83996045..84071408)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing.
Title: Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3ζ in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.
functional T cells are required for the full development of Dahl salt-sensitive hypertension and indicate that the association between CD247 and hypertension in humans may be related to altered immune cell function.
Title: CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.
ectopic CD3zeta expression in neural precursor stem cells impaired their normal cell-fate specification. Variations of CD3zeta expression in the developing CNS might result in neurodevelopmental anomalies.
Title: Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification.
The transmembrane adaptor signaling protein CD3zeta, first described in the immune system, has a previously uncharacterized role in regulating neuronal development.
Title: The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
Tere is a robust postnatal up-regulation of CD3-zeta in rat hippocampus in early postnatal period.
Title: Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus.
experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta
Title: Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.

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General gene information

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Markers

RH94658 (e-PCR)
- UniSTS:119905

RH94479 (e-PCR)
- UniSTS:119727

PMC197251P5 (e-PCR)
- UniSTS:271854

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Fc-gamma receptor III complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of alpha-beta T cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha-beta T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD3 zeta chain

Names: CD247 antigen; CD3 antigen, zeta polypeptide; T-cell receptor CD3, subunit zeta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205304.1 → NP_001192233.1 T-cell surface glycoprotein CD3 zeta chain isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC097933, CO562119, JAXUCZ010000013

UniProtKB/TrEMBL

M0R576, Q4V7G0

Related

ENSRNOP00000104978.1, ENSRNOT00000143775.1

Conserved Domains (2) summary

pfam02189
Location:112 → 131

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:28 → 58

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain
NM_170789.2 → NP_740770.2 T-cell surface glycoprotein CD3 zeta chain isoform 1

See identical proteins and their annotated locations for NP_740770.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC097933, JAXUCZ010000013

UniProtKB/TrEMBL

A6IDI4, F7FGL4, Q4V7G0

Related

ENSRNOP00000004403.5, ENSRNOT00000004403.10

Conserved Domains (3) summary

smart00077
Location:69 → 89

ITAM; Immunoreceptor tyrosine-based activation motif

pfam02189
Location:139 → 158

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:28 → 58

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

80576264..80651422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250147.4 → XP_006250209.1 T-cell surface glycoprotein CD3 zeta chain isoform X1

UniProtKB/TrEMBL

A6IDI4

Conserved Domains (3) summary

smart00077
Location:69 → 89

ITAM; Immunoreceptor tyrosine-based activation motif

pfam02189
Location:138 → 157

ITAM; Immunoreceptor tyrosine-based activation motif

pfam11628
Location:28 → 58

TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain