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    Kcnk12 potassium two pore domain channel subfamily K member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnk12provided by RGD
    Official Full Name
    potassium two pore domain channel subfamily K member 12provided by RGD
    Primary source
    RGD:68940
    See related
    EnsemblRapid:ENSRNOG00000016110 AllianceGenome:RGD:68940
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    THIK-2
    Summary
    Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905828.1 and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnk12 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12492609..12544250)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (6740147..6790664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11373917..11494459, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene F-box protein 11 Neighboring gene mutS homolog 6 Neighboring gene uncharacterized LOC134479271 Neighboring gene uncharacterized LOC120103460 Neighboring gene mutS homolog 2 Neighboring gene epithelial cell adhesion molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Renigunta V, et al. Pflugers Arch, 2014 Sep. PMID 24297522
    2. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. Rajan S, et al. J Biol Chem, 2001 Mar 9. PMID 11060316
    3. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Theilig F, et al. Cell Physiol Biochem, 2008. PMID 18209473
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the characteristics of THIK-2 channels can be analysed in heterologous expression systems by using trafficking and/or gating mutants
      Title: Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.
    2. THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
      Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 12
    Names
    potassium channel, subfamily K, member 12
    potassium channel, two pore domain subfamily K, member 12
    tandem pore domain halothane-inhibited potassium channel 2
    tandem pore domain potassium channel THIK-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022292.2 → NP_071628.1  potassium channel subfamily K member 12

      See identical proteins and their annotated locations for NP_071628.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q9ERS1
      UniProtKB/TrEMBL
      A6H9C8
      Related
      ENSRNOP00000021570.1, ENSRNOT00000021570.4
      Conserved Domains (1) summary
      pfam07885
      Location:222 → 304
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      12492609..12544250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112871.2 → XP_038968799.1  potassium channel subfamily K member 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZT0
      Conserved Domains (1) summary
      pfam07885
      Location:313 → 395
      Ion_trans_2; Ion channel

    2. XM_039112873.2 → XP_038968801.1  potassium channel subfamily K member 12 isoform X2

      Conserved Domains (1) summary
      pfam07885
      Location:89 → 171
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERS1.1 GenPept UniProtKB/Swiss-Prot:Q9ERS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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