Duox2 dual oxidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Duox2provided by RGD
Official Full Name: dual oxidase 2provided by RGD
Primary source: RGD:628761
See related: EnsemblRapid:ENSRNOG00000017395 AllianceGenome:RGD:628761
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Thox2
Summary: Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in several processes, including hydrogen peroxide biosynthetic process; response to cAMP; and superoxide anion generation. Predicted to act upstream of or within several processes, including bone mineralization; endocrine system development; and thyroid hormone metabolic process. Predicted to be located in several cellular components, including cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 3.4), Thymus (RPKM 3.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (129680543..129698886, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (109223809..109247023, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (114218187..114237808, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nis and Duox2 are two novel direct transcriptional regulation FoxE1 targets in thyroid follicular cells.
Title: New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Duox2 (e-PCR), detects polymorphism
- UniSTS:525522

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD(P)H oxidase H2O2-forming activity	IEA Inferred from Electronic Annotation more info
enables NAD(P)H oxidase H2O2-forming activity	ISO Inferred from Sequence Orthology more info
enables NADH oxidase H202-forming activity	IEA Inferred from Electronic Annotation more info
enables NADPH oxidase H202-forming activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NAD(P)H oxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenohypophysis morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenohypophysis morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cuticle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual oxidase 2

Names: NADH/NADPH thyroid oxidase THOX2; large NOX 2; long NOX 2; thyroid oxidase 2

NP_077055.2

EC 1.6.3.1

XP_038961822.1

EC 1.6.3.1

XP_063140672.1

EC 1.6.3.1

XP_063140673.1

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024141.2 → NP_077055.2 dual oxidase 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q811Y4, Q9ES45

UniProtKB/TrEMBL

A6HPS6

Conserved Domains (5) summary

cd06186
Location:1243 → 1517

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:38 → 594

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

COG5126
Location:719 → 856

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:824 → 885

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam01794
Location:1057 → 1201

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

129680543..129698886 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105894.2 → XP_038961822.1 dual oxidase 2 isoform X1

UniProtKB/Swiss-Prot

Q811Y4, Q9ES45

Related

ENSRNOP00000023939.4, ENSRNOT00000023939.6

Conserved Domains (7) summary

cd06186
Location:1239 → 1513

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:38 → 594

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

COG5126
Location:719 → 856

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:824 → 885

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd15898
Location:823 → 852

EFh_PI-PLC; EF-hand motif [structural motif]

cl28895
Location:823 → 947

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

pfam01794
Location:1053 → 1197

Ferric_reduct; Ferric reductase like transmembrane component
XM_063284602.1 → XP_063140672.1 dual oxidase 2 isoform X2

UniProtKB/Swiss-Prot

Q811Y4, Q9ES45
XM_063284603.1 → XP_063140673.1 dual oxidase 2 isoform X3

UniProtKB/Swiss-Prot

Q811Y4, Q9ES45