Clca4l chloride channel calcium activated 4-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clca4lprovided by RGD
Official Full Name: chloride channel calcium activated 4-likeprovided by RGD
Primary source: RGD:1591945
See related: EnsemblRapid:ENSRNOG00000036877 AllianceGenome:RGD:1591945
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rbclca2
Summary: Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human CLCA3P (chloride channel accessory 3, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 11.3), Spleen (RPKM 5.0) and 7 other tissues See more
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Genomic context

Location:: 2q44

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (236486485..236506483, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (233826133..233846137, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (250785534..250805445, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cloned and expressed CLCA4L from rat olfactory epithelium in HEK293 cells. In the transfected HEK293 cells we measured a Cl(-)-selective Ca(2+)-activated current, blocked by niflumic acid, not present in the non-transfected cells. CLCA4L mimics the CLCA1 current on its ability to induce the ANO1-dependent Ca(2+)-activated Cl(-) current endogenous to these cells. A CLCA protein was detected in olfactory receptor cell cilia
Title: A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca(2+)-activated Cl(-) current when transfected into HEK293.
Using rbCLCA1 sequence, gene rbCLCA2 was cloned containing sites for signal peptide cleavage, N-linked glycosylation and phosphorylation by PKC, cAMP- and cGMP-dependent protein kinases,tyrosine kinase and casein II. rbCLCA2 current is Ca(2+) dependent.
Title: Cloning and heterologous expression of a Ca2+-activated chloride channel isoform from rat brain.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chloride channel calcium activated 4-like

Names: calcium-activated chloride channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077356.2 → NP_001070824.1 chloride channel calcium activated 4-like precursor

See identical proteins and their annotated locations for NP_001070824.1

Status: PROVISIONAL

Source sequence(s)

AB256513

UniProtKB/TrEMBL

A6HW99, Q05KA7

Related

ENSRNOP00000052230.4, ENSRNOT00000055362.4

Conserved Domains (3) summary

cd00198
Location:307 → 464

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam08434
Location:24 → 889

CLCA; Calcium-activated chloride channel

cl19929
Location:532 → 572

A2M_N; MG2 domain