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    Mtss2 MTSS I-BAR domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtss2provided by RGD
    Official Full Name
    MTSS I-BAR domain containing 2provided by RGD
    Primary source
    RGD:1309731
    See related
    EnsemblRapid:ENSRNOG00000017500 AllianceGenome:RGD:1309731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abba-1; Mtss1l; RGD1309731
    Summary
    Predicted to enable several functions, including GTPase activator activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cell projection assembly; and cellular response to platelet-derived growth factor stimulus. Predicted to act upstream of or within lamellipodium organization. Predicted to be located in cortical actin cytoskeleton; lamellipodium; and ruffle membrane. Predicted to be active in actin cytoskeleton and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Orthologous to human MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 138.2), Brain (RPKM 97.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtss2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55602180..55623955)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38692793..38714575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (40904779..40925660, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene VAC14 component of PIKFYVE complex Neighboring gene transfer RNA glycine (anticodon GCC) 9 Neighboring gene uncharacterized LOC134483369 Neighboring gene uncharacterized LOC134483366 Neighboring gene interleukin 34 Neighboring gene ribosomal protein L29 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1. Zheng D, et al. Biochem Biophys Res Commun, 2010 Oct 29. PMID 20875796, Free PMC Article
    2. ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension. Saarikangas J, et al. J Cell Sci, 2008 May 1. PMID 18413296
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lamellipodium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MTSS 2
    Names
    MTSS1-like protein
    MTSS1L, I-BAR domain containing
    actin-bundling protein with BAIAP2 homology
    metastasis suppressor 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191558.1 → NP_001178487.1  protein MTSS 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZL76
      Conserved Domains (1) summary
      cd07643
      Location:6 → 236
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55602180..55623955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097762.2 → XP_038953690.1  protein MTSS 2 isoform X1

      UniProtKB/TrEMBL
      D4A3S6
      Conserved Domains (2) summary
      cd07643
      Location:6 → 236
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      cd22060
      Location:735 → 765
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    2. XM_063278057.1 → XP_063134127.1  protein MTSS 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL76

    3. XM_039097765.2 → XP_038953693.1  protein MTSS 2 isoform X2

      UniProtKB/TrEMBL
      D4A3S6
      Related
      ENSRNOP00000023645.6, ENSRNOT00000023645.7
      Conserved Domains (2) summary
      cd07643
      Location:6 → 236
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      cd22060
      Location:716 → 746
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    4. XM_063278058.1 → XP_063134128.1  protein MTSS 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AHN6
    Nucleotide Protein Strain
    Heading Accession and Version

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