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    Trps1 transcriptional repressor GATA binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trps1provided by RGD
    Official Full Name
    transcriptional repressor GATA binding 1provided by RGD
    Primary source
    RGD:1311883
    See related
    EnsemblRapid:ENSRNOG00000024998 AllianceGenome:RGD:1311883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including hair follicle development; negative regulation of transcription by RNA polymerase II; and regulation of chondrocyte differentiation. Predicted to act upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 158.2), Thymus (RPKM 106.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trps1 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (83806121..84032609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (81916668..82142733, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (90085895..90320430, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479727 Neighboring gene uncharacterized LOC134479603 Neighboring gene uncharacterized LOC120093649 Neighboring gene uncharacterized LOC102548590 Neighboring gene uncharacterized LOC102548754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The atypical GATA protein TRPS1 represses androgen-induced prostate-specific antigen expression in LNCaP prostate cancer cells. van den Bemd GJ, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680804
    2. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Momeni P, et al. Nat Genet, 2000 Jan. PMID 10615131
    3. The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. Kaiser FJ, et al. J Biol Chem, 2003 Oct 3. PMID 12885770
    4. Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. Fantauzzo KA, et al. PLoS Genet, 2012. PMID 23133399, Free PMC Article
    5. TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Stinson S, et al. Sci Signal, 2011 Jun 14. PMID 21673316

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger transcription factor Trps1
    Names
    trichorhinophalangeal syndrome I homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134837.1 → NP_001128309.1  zinc finger transcription factor Trps1

      See identical proteins and their annotated locations for NP_001128309.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I5Y133, A6HRD1
      Related
      ENSRNOP00000096700.1, ENSRNOT00000110775.2
      Conserved Domains (2) summary
      smart00401
      Location:891 → 934
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:895 → 951
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      83806121..84032609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078765.2 → XP_038934693.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6
      Related
      ENSRNOP00000039913.3, ENSRNOT00000050774.4

    2. XM_039078762.2 → XP_038934690.1  zinc finger transcription factor Trps1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000083606.2, ENSRNOT00000106247.2
      Conserved Domains (1) summary
      cd00202
      Location:910 → 966
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    3. XM_063263244.1 → XP_063119314.1  zinc finger transcription factor Trps1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y133, A0A8I5ZWX6
      Related
      ENSRNOP00000110301.1, ENSRNOT00000157182.1

    4. XM_039078768.2 → XP_038934696.1  zinc finger transcription factor Trps1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000077022.1, ENSRNOT00000094294.2

    5. XM_039078760.2 → XP_038934688.1  zinc finger transcription factor Trps1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y133
      Conserved Domains (1) summary
      cd00202
      Location:933 → 989
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    6. XM_039078761.2 → XP_038934689.1  zinc finger transcription factor Trps1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000110847.1, ENSRNOT00000146817.1

    7. XM_039078767.2 → XP_038934695.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6

    8. XM_039078764.2 → XP_038934692.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6
      Conserved Domains (1) summary
      cd00202
      Location:906 → 962
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein Strain
    Heading Accession and Version

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