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    Esrp1 epithelial splicing regulatory protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esrp1provided by RGD
    Official Full Name
    epithelial splicing regulatory protein 1provided by RGD
    Primary source
    RGD:1560481
    See related
    EnsemblRapid:ENSRNOG00000008184 AllianceGenome:RGD:1560481
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560481
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing and regulation of inner ear auditory receptor cell fate specification. Predicted to act upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nuclear body. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 53.7), Kidney (RPKM 28.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esrp1 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (29224831..29279381, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (24427611..24482157, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (24576988..24631758, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19 like 4 Neighboring gene ribosomal protein S23, pseudogene 1 Neighboring gene enolase 1, pseudogene 21 Neighboring gene ribosomal protein L24 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epithelial splicing regulator protein 1 and alternative splicing in somatotroph adenomas. Lekva T, et al. Endocrinology, 2013 Sep. PMID 23825128
    2. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Warzecha CC, et al. Mol Cell, 2009 Mar 13. PMID 19285943, Free PMC Article
    3. ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Rohacek AM, et al. Dev Cell, 2017 Nov 6. PMID 29107558, Free PMC Article
    4. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of inner ear auditory receptor cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inner ear auditory receptor cell fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epithelial splicing regulatory protein 1
    Names
    RNA-binding motif protein 35A
    RNA-binding protein 35A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127564.2 → NP_001121036.2  epithelial splicing regulatory protein 1

      See identical proteins and their annotated locations for NP_001121036.2

      Status: PROVISIONAL

      Source sequence(s)
      BC166735
      UniProtKB/Swiss-Prot
      B2RYD2
      Conserved Domains (6) summary
      COG0724
      Location:285 → 473
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310 → 418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444 → 524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29 → 168
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:630 → 658
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      29224831..29279381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288192.1 → XP_063144262.1  epithelial splicing regulatory protein 1 isoform X7

      UniProtKB/Swiss-Prot
      B2RYD2

    2. XM_063288193.1 → XP_063144263.1  epithelial splicing regulatory protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RYD2
      UniProtKB/TrEMBL
      A0A8I6APB2, A6JFT3
      Related
      ENSRNOP00000095508.1, ENSRNOT00000110297.2

    3. XM_006237878.5 → XP_006237940.1  epithelial splicing regulatory protein 1 isoform X4

      UniProtKB/Swiss-Prot
      B2RYD2
      UniProtKB/TrEMBL
      A0A8L2QVS8
      Related
      ENSRNOP00000063046.2, ENSRNOT00000067129.6
      Conserved Domains (6) summary
      COG0724
      Location:285 → 473
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310 → 418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444 → 524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29 → 168
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:634 → 662
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_006237880.5 → XP_006237942.1  epithelial splicing regulatory protein 1 isoform X6

      UniProtKB/Swiss-Prot
      B2RYD2
      Conserved Domains (5) summary
      COG0724
      Location:285 → 473
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310 → 418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444 → 524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29 → 168
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    5. XM_063288195.1 → XP_063144265.1  epithelial splicing regulatory protein 1 isoform X10

    6. XM_063288196.1 → XP_063144266.1  epithelial splicing regulatory protein 1 isoform X11

    7. XM_063288190.1 → XP_063144260.1  epithelial splicing regulatory protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RYD2
      UniProtKB/TrEMBL
      F1LP81
      Related
      ENSRNOP00000010846.6, ENSRNOT00000010846.8

    8. XM_063288191.1 → XP_063144261.1  epithelial splicing regulatory protein 1 isoform X5

      UniProtKB/Swiss-Prot
      B2RYD2
      UniProtKB/TrEMBL
      A0A8I6AFU1
      Related
      ENSRNOP00000092072.1, ENSRNOT00000110555.2

    9. XM_039110538.2 → XP_038966466.1  epithelial splicing regulatory protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RYD2
      Conserved Domains (4) summary
      cd12739
      Location:309 → 419
      RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:443 → 523
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29 → 168
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:216 → 307
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_006237877.5 → XP_006237939.1  epithelial splicing regulatory protein 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RYD2
      Conserved Domains (6) summary
      COG0724
      Location:285 → 473
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12736
      Location:221 → 305
      RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12739
      Location:310 → 418
      RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:444 → 524
      RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:29 → 168
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:630 → 668
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_039110539.2 → XP_038966467.1  epithelial splicing regulatory protein 1 isoform X9

      Conserved Domains (3) summary
      cd12739
      Location:138 → 248
      RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:272 → 352
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl17169
      Location:44 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_039110540.2 → XP_038966468.1  epithelial splicing regulatory protein 1 isoform X9

      Conserved Domains (3) summary
      cd12739
      Location:138 → 248
      RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
      cd12742
      Location:272 → 352
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl17169
      Location:44 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RYD2.2 GenPept UniProtKB/Swiss-Prot:B2RYD2

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