Stk11 serine/threonine kinase 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk11provided by RGD
Official Full Name: serine/threonine kinase 11provided by RGD
Primary source: RGD:1308653
See related: EnsemblRapid:ENSRNOG00000014287 AllianceGenome:RGD:1308653
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lkb1
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of gluconeogenesis; response to glucagon; and response to thyroid hormone. Located in Z disc. Part of protein-containing complex. Biomarker of hyperthyroidism and obesity. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 222.0), Muscle (RPKM 176.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10225204..10241965, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9574553..9591315, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12440751..12457513, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury.
Title: LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury.
Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling.
Title: Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling.
CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Title: CD4(+) T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-kappaB) Activation.
Title: Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation.
Paeoniflorin mitigated the intestinal I/R-impaired autophagy flux by activating LKB1/AMPK signaling pathway.
Title: Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.
findings demonstrate that antagonizing PPARgamma promotes the M1-to-M2 phenotypic shift in LPS-induced microglia, which might be due to improved autophagy via the activation of the LKB1-AMPK signaling pathway
Title: Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
effectively inhibits oxidative stress via modulating antioxidative enzymes and activating the LKB1/AMPK signaling pathway in the process of acute cerebral infarct.
Title: An Antioxidant Role by Minocycline Via Enhancing the Activation of LKB1/AMPK Signaling in the Process of Cerebral Ischemia Injury.
Genistein-dependent autophagy diminishes vascular smooth muscle cell senescence via an LKB1-AMPK-dependent mechanism.
Title: Genistein-induced LKB1-AMPK activation inhibits senescence of VSMC through autophagy induction.
Lkb1 role in adipogenesis.The functional relationship between LKB1 and mTOR in regulating adipogenesis.
Title: mTOR remains unchanged in diet-resistant (DR) rats despite impaired LKB1/AMPK cascade in adipose tissue.
LKB1 complex proteins have a role in myofilament function and myocellular "energy" sensing in the heart
Title: Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_3363-3364:991937109:1 (e-PCR)
- UniSTS:231020

Stk11 (e-PCR), detects polymorphism
- UniSTS:546518

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables LRR domain binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Golgi localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in anoikis	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of intracellular protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of serine/threonine protein kinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase STK11

Names: liver kinase B1 homolog; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1

NP_001101539.1

EC 2.7.11.1

XP_008763318.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108069.3 → NP_001101539.1 serine/threonine-protein kinase STK11

See identical proteins and their annotated locations for NP_001101539.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

A0A0H2UI02, D4A179, D4AE59

UniProtKB/TrEMBL

A6K8R3

Related

ENSRNOP00000109626.1, ENSRNOT00000138015.1

Conserved Domains (1) summary

cd14119
Location:55 → 309

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10225204..10241965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765096.2 → XP_008763318.1 serine/threonine-protein kinase STK11 isoform X1

See identical proteins and their annotated locations for XP_008763318.1

UniProtKB/Swiss-Prot

A0A0H2UI02, D4A179, D4AE59

UniProtKB/TrEMBL

A6K8R3

Conserved Domains (1) summary

cd14119
Location:55 → 309

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1