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    Pop5 POP5 homolog, ribonuclease P/MRP subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pop5provided by RGD
    Official Full Name
    POP5 homolog, ribonuclease P/MRP subunitprovided by RGD
    Primary source
    RGD:1311819
    See related
    EnsemblRapid:ENSRNOG00000001199 AllianceGenome:RGD:1311819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rpP2; Rnasep3
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to act upstream of or within tRNA processing. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Predicted to be active in nucleolus. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 141.3), Heart (RPKM 88.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pop5 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47037451..47045778, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41376755..41384882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47138346..47143152, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096006 Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ring finger protein 10 Neighboring gene calcium binding protein 1 Neighboring gene uncharacterized LOC134481303 Neighboring gene uncharacterized LOC102548245

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. van Eenennaam H, et al. J Biol Chem, 2001 Aug 24. PMID 11413139
    2. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
    3. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P/MRP protein subunit POP5
    Names
    processing of precursor 5, ribonuclease P/MRP family
    processing of precursor 5, ribonuclease P/MRP subunit
    ribonuclease P protein 3
    NP_001099222.2
    XP_017453738.1
    XP_063127091.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105752.2 → NP_001099222.2  ribonuclease P/MRP protein subunit POP5

      See identical proteins and their annotated locations for NP_001099222.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1W0, A6J1W1, D3ZY31
      Related
      ENSRNOP00000001591.6, ENSRNOT00000001591.9
      Conserved Domains (1) summary
      pfam01900
      Location:7 → 115
      RNase_P_Rpp14; Rpp14/Pop5 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47037451..47045778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598249.3 → XP_017453738.1  ribonuclease P/MRP protein subunit POP5 isoform X1

      UniProtKB/TrEMBL
      A6J1W0, A6J1W1, D3ZY31
      Conserved Domains (1) summary
      pfam01900
      Location:7 → 115
      RNase_P_Rpp14; Rpp14/Pop5 family

    2. XM_063271021.1 → XP_063127091.1  ribonuclease P/MRP protein subunit POP5 isoform X1

      UniProtKB/TrEMBL
      A6J1W0, A6J1W1, D3ZY31
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials