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    Il36rn interleukin 36 receptor antagonist [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il36rnprovided by RGD
    Official Full Name
    interleukin 36 receptor antagonistprovided by RGD
    Primary source
    RGD:1311212
    See related
    EnsemblRapid:ENSRNOG00000005751 AllianceGenome:RGD:1311212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Il1f5
    Summary
    Predicted to enable cytokine activity and interleukin-1 receptor binding activity. Predicted to be involved in several processes, including antifungal humoral response; cellular response to lipopolysaccharide; and negative regulation of cytokine production. Predicted to act upstream of or within negative regulation of interleukin-6 production. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pustular psoriasis 14. Orthologous to human IL36RN (interleukin 36 receptor antagonist). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 5.4), Liver (RPKM 3.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il36rn in Genome Data Viewer
    Location:
    3p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (27442679..27449306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7044419..7051016)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (1385256..1392275)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene interleukin 36, gamma Neighboring gene ribosomal protein L23a, pseudogene 10 Neighboring gene interleukin 36, alpha Neighboring gene interleukin 36, beta Neighboring gene interleukin 1 family member 10 Neighboring gene interleukin 1 receptor antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Luo C, et al. Med Sci Monit, 2020 Feb 12. PMID 32048631, Free PMC Article
    2. The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. Gresnigt MS, et al. Eur J Immunol, 2013 Feb. PMID 23147407
    3. IL-36R ligands are potent regulators of dendritic and T cells. Vigne S, et al. Blood, 2011 Nov 24. PMID 21860022
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-36 receptor antagonist protein
    Names
    interleukin 1 family, member 5 (delta)
    interleukin-1 family member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107814.2 → NP_001101284.1  interleukin-36 receptor antagonist protein

      See identical proteins and their annotated locations for NP_001101284.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JSX9, D4A1A6
      Related
      ENSRNOP00000007593.4, ENSRNOT00000007593.6
      Conserved Domains (1) summary
      cl00094
      Location:10 → 153
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    2. NM_001434166.1 → NP_001421095.1  interleukin-36 receptor antagonist protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JSX9, D4A1A6

    3. NM_001434167.1 → NP_001421096.1  interleukin-36 receptor antagonist protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JSX9, D4A1A6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      27442679..27449306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283914.1 → XP_063139984.1  interleukin-36 receptor antagonist protein isoform X1

    2. XM_039105176.2 → XP_038961104.1  interleukin-36 receptor antagonist protein isoform X1

      Conserved Domains (1) summary
      cl00094
      Location:10 → 153
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    Nucleotide Protein Strain
    Heading Accession and Version

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