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    Fes FES proto-oncogene, tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fesprovided by RGD
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by RGD
    Primary source
    RGD:1564385
    See related
    EnsemblRapid:ENSRNOG00000011683 AllianceGenome:RGD:1564385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564385
    Summary
    Predicted to enable several functions, including immunoglobulin receptor binding activity; microtubule binding activity; and non-membrane spanning protein tyrosine kinase activity. Involved in cardiac muscle cell proliferation and myoblast proliferation. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 71.6), Spleen (RPKM 64.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fes in Genome Data Viewer
    Location:
    1q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143746945..143756181, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134337698..134346934, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142174648..142183884, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A like 7 Neighboring gene HD domain containing 3 Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene uncharacterized LOC102553801 Neighboring gene furin (paired basic amino acid cleaving enzyme) Neighboring gene uncharacterized LOC134483745 Neighboring gene uncharacterized LOC108349447

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction. Zhang C, et al. J Gastroenterol Hepatol, 2019 Oct. PMID 31038805
    2. Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients. Kuo IY, et al. Int J Med Sci, 2014. PMID 24936140, Free PMC Article
    3. K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation. Yu G, et al. J Biol Chem, 1989 Jun 15. PMID 2656706
    4. Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713). Hjermstad SJ, et al. Oncogene, 1993 Aug. PMID 7687763
    5. Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking. Zirngibl R, et al. Exp Cell Res, 2001 May 15. PMID 11339827

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A 95 kDa Fes protein was purified from the rat brain CRMP-CRAM complex and shown to be involved in Sema3A signaling [Fes].
      Title: Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.
    2. Fes and Bcr cooperate to activate Rho family GTPases as part of a novel pathway regulating neurite extension in PC12 cells, and provide more evidence for an emerging role for Fes in neuronal differentiation.
      Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to vitamin D ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    feline sarcoma oncogene
    NP_001101958.1
    XP_038938259.1
    XP_063123003.1
    XP_063123011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108488.1 → NP_001101958.1  tyrosine-protein kinase Fes/Fps

      See identical proteins and their annotated locations for NP_001101958.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A0A8I5ZWJ2, A6JCB2, D4A584
      Related
      ENSRNOP00000016032.5, ENSRNOT00000016032.7
      Conserved Domains (4) summary
      cd07685
      Location:7 → 239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:561 → 814
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:564 → 815
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143746945..143756181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266933.1 → XP_063123003.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A6JCB7

    2. XM_039082331.2 → XP_038938259.1  tyrosine-protein kinase Fes/Fps isoform X2

      Conserved Domains (2) summary
      cd07685
      Location:7 → 239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 513
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

    3. XM_063266941.1 → XP_063123011.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B2GV16

    RNA

    1. XR_350521.5 RNA Sequence

    2. XR_005488133.2 RNA Sequence

    3. XR_005488136.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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