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    Osgin2 oxidative stress induced growth inhibitor family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osgin2provided by RGD
    Official Full Name
    oxidative stress induced growth inhibitor family member 2provided by RGD
    Primary source
    RGD:1306323
    See related
    EnsemblRapid:ENSRNOG00000009358 AllianceGenome:RGD:1306323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306323
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. Orthologous to human OSGIN2 (oxidative stress induced growth inhibitor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 101.7), Heart (RPKM 57.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osgin2 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (34297417..34316353, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (29500406..29519340, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (29663131..29683634, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L30, pseudogene 6 Neighboring gene nibrin Neighboring gene tubulin, alpha 2 like, pseudogene 1 Neighboring gene GA binding protein transcription factor subunit beta 2, pseudogene 1 Neighboring gene receptor-interacting serine-threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-induced growth inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399569.1 → NP_001386498.1  oxidative stress-induced growth inhibitor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6ASB1, A6IIB1, D3ZB49
      Related
      ENSRNOP00000012394.4, ENSRNOT00000012394.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      34297417..34316353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237919.5 → XP_006237981.1  oxidative stress-induced growth inhibitor 2 isoform X1

      See identical proteins and their annotated locations for XP_006237981.1

      UniProtKB/TrEMBL
      A0A8I6ASB1, A6IIB2
      Conserved Domains (1) summary
      PRK12770
      Location:258 → 333
      PRK12770; putative glutamate synthase subunit beta; Provisional

    2. XM_063287579.1 → XP_063143649.1  oxidative stress-induced growth inhibitor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ASB1
      Related
      ENSRNOP00000092835.2, ENSRNOT00000095460.2

    3. XM_039110948.1 → XP_038966876.1  oxidative stress-induced growth inhibitor 2 isoform X3

      UniProtKB/TrEMBL
      A6IIB3
      Conserved Domains (1) summary
      PRK12770
      Location:125 → 200
      PRK12770; putative glutamate synthase subunit beta; Provisional

    4. XM_063287580.1 → XP_063143650.1  oxidative stress-induced growth inhibitor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKD4

    5. XM_039110950.2 → XP_038966878.1  oxidative stress-induced growth inhibitor 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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