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    Zfpm2 zinc finger protein, multitype 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfpm2provided by RGD
    Official Full Name
    zinc finger protein, multitype 2provided by RGD
    Primary source
    RGD:1306021
    See related
    EnsemblRapid:ENSRNOG00000004109 AllianceGenome:RGD:1306021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FOG-2
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including cardiac chamber morphogenesis; positive regulation of cardiac muscle cell proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including circulatory system development; in utero embryonic development; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; male germ cell nucleus; and nucleoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 57.6), Brain (RPKM 35.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfpm2 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (73563732..74001041)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (71678658..72116209)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (79471277..79964405)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692893 Neighboring gene uncharacterized LOC108351485 Neighboring gene uncharacterized LOC120093643 Neighboring gene uncharacterized LOC134479716 Neighboring gene uncharacterized LOC120093644 Neighboring gene uncharacterized LOC120093645 Neighboring gene uncharacterized LOC102556196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples. Sheng W, et al. Pediatr Res, 2016 Jul. PMID 26959486
    2. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, et al. Nat Commun, 2015 Feb 17. PMID 25687237, Free PMC Article
    3. The miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation of mouse embryonic cardiomyocytes. Xiang R, et al. Braz J Med Biol Res, 2012 Feb. PMID 22267003, Free PMC Article
    4. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. Pizzuti A, et al. Hum Mutat, 2003 Nov. PMID 14517948
    5. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Klarin D, et al. Circ Cardiovasc Genet, 2017 Apr. PMID 28373160, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOG-2 represses hypertrophic responses in cardiac myocytes and that p300 is involved in these repressive effects
      Title: FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes.
    2. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with this cardiac-enriched repressor protein (FOG-2)
      Title: Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outflow tract septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in right ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZFPM2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130501.2 → NP_001123973.1  zinc finger protein ZFPM2 isoform 1

      See identical proteins and their annotated locations for NP_001123973.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HR90, D4A0R1
      Related
      ENSRNOP00000035072.7, ENSRNOT00000029419.8
      Conserved Domains (2) summary
      sd00017
      Location:301 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:298 → 386
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001434579.1 → NP_001421508.1  zinc finger protein ZFPM2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      73563732..74001041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079162.2 → XP_038935090.1  zinc finger protein ZFPM2 isoform X1

      Related
      ENSRNOP00000103913.1, ENSRNOT00000171636.1
      Conserved Domains (2) summary
      sd00017
      Location:248 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19216
      Location:44 → 154
      PR-SET_ZFPM2; PR-SET domain found in zinc finger protein ZFPM2 and similar proteins

    2. XM_039079163.2 → XP_038935091.1  zinc finger protein ZFPM2 isoform X2

      Related
      ENSRNOP00000099393.1, ENSRNOT00000128336.1
      Conserved Domains (2) summary
      sd00017
      Location:207 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:47 → 113
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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