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    Ttll3 tubulin tyrosine ligase like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttll3provided by RGD
    Official Full Name
    tubulin tyrosine ligase like 3provided by RGD
    Primary source
    RGD:1311255
    See related
    EnsemblRapid:ENSRNOG00000009032 AllianceGenome:RGD:1311255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-glycine ligase activity, initiating. Predicted to be involved in several processes, including axoneme assembly; flagellated sperm motility; and protein polyglycylation. Predicted to act upstream of or within cilium assembly. Predicted to be located in cilium. Predicted to be active in axoneme; microtubule cytoskeleton; and sperm flagellum. Orthologous to human TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 65.1), Kidney (RPKM 26.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148088575..148113526)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146532958..146558425)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145341059..145366614)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene transcriptional adaptor 3 Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene uncharacterized LOC102548450 Neighboring gene cell death-inducing DFFA-like effector c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. Bosch Grau M, et al. J Cell Biol, 2013 Aug 5. PMID 23897886, Free PMC Article
    2. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-glycine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glycine ligase activity, initiating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, initiating ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in protein polyglycylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyglycylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin monoglycylase TTLL3
    Names
    tubulin tyrosine ligase-like family, member 3
    NP_001102110.2
    XP_038963762.1
    XP_038963763.1
    XP_038963764.1
    XP_038963765.1
    XP_038963766.1
    XP_038963767.1
    XP_038963768.1
    XP_038963769.1
    XP_038963770.1
    XP_038963771.1
    XP_038963772.1
    XP_038963773.1
    XP_038963775.1
    XP_038963776.1
    XP_038963778.1
    XP_038963779.1
    XP_038963780.1
    XP_038963781.1
    XP_038963782.1
    XP_038963783.1
    XP_063142363.1
    XP_063142364.1
    XP_063142365.1
    XP_063142366.1
    XP_063142367.1
    XP_063142368.1
    XP_063142369.1
    XP_063142370.1
    XP_063142371.1
    XP_063142372.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108640.2 → NP_001102110.2  tubulin monoglycylase TTLL3 isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      BC168907, CV126544
      UniProtKB/TrEMBL
      B5DF33, D3ZE22
      Related
      ENSRNOP00000076428.2, ENSRNOT00000102169.2
      Conserved Domains (1) summary
      pfam03133
      Location:288 → 580
      TTL; Tubulin-tyrosine ligase family

    2. NM_001429192.1 → NP_001416121.1  tubulin monoglycylase TTLL3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    3. NM_001429194.1 → NP_001416123.1  tubulin monoglycylase TTLL3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    4. NM_001429195.1 → NP_001416124.1  tubulin monoglycylase TTLL3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    5. NM_001429197.1 → NP_001416126.1  tubulin monoglycylase TTLL3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    6. NM_001429199.1 → NP_001416128.1  tubulin monoglycylase TTLL3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    7. NM_001429200.1 → NP_001416129.1  tubulin monoglycylase TTLL3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      B5DF33

    8. NM_001429203.1 → NP_001416132.1  tubulin monoglycylase TTLL3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    9. NM_001429204.1 → NP_001416133.1  tubulin monoglycylase TTLL3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    10. NM_001429205.1 → NP_001416134.1  tubulin monoglycylase TTLL3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5Y527

    11. NM_001429206.1 → NP_001416135.1  tubulin monoglycylase TTLL3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ABR5

    12. NM_001429207.1 → NP_001416136.1  tubulin monoglycylase TTLL3 isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      B5DF33

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148088575..148113526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107845.2 → XP_038963773.1  tubulin monoglycylase TTLL3 isoform X16

      Conserved Domains (1) summary
      pfam03133
      Location:288 → 592
      TTL; Tubulin-tyrosine ligase family

    2. XM_063286301.1 → XP_063142371.1  tubulin monoglycylase TTLL3 isoform X26

    3. XM_063286298.1 → XP_063142368.1  tubulin monoglycylase TTLL3 isoform X19

    4. XM_063286299.1 → XP_063142369.1  tubulin monoglycylase TTLL3 isoform X21

    5. XM_063286302.1 → XP_063142372.1  tubulin monoglycylase TTLL3 isoform X28

      UniProtKB/TrEMBL
      A0A8I5Y527

    6. XM_039107847.2 → XP_038963775.1  tubulin monoglycylase TTLL3 isoform X17

      Conserved Domains (1) summary
      pfam03133
      Location:287 → 591
      TTL; Tubulin-tyrosine ligase family

    7. XM_039107843.2 → XP_038963771.1  tubulin monoglycylase TTLL3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 743
      TTL; Tubulin-tyrosine ligase family

    8. XM_039107842.2 → XP_038963770.1  tubulin monoglycylase TTLL3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 743
      TTL; Tubulin-tyrosine ligase family

    9. XM_039107834.2 → XP_038963762.1  tubulin monoglycylase TTLL3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 743
      TTL; Tubulin-tyrosine ligase family

    10. XM_039107837.2 → XP_038963765.1  tubulin monoglycylase TTLL3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 743
      TTL; Tubulin-tyrosine ligase family

    11. XM_039107851.2 → XP_038963779.1  tubulin monoglycylase TTLL3 isoform X24

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 743
      TTL; Tubulin-tyrosine ligase family

    12. XM_039107844.2 → XP_038963772.1  tubulin monoglycylase TTLL3 isoform X14

      Related
      ENSRNOP00000088967.2, ENSRNOT00000107721.2
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 731
      TTL; Tubulin-tyrosine ligase family

    13. XM_063286295.1 → XP_063142365.1  tubulin monoglycylase TTLL3 isoform X12

      Related
      ENSRNOP00000012015.7, ENSRNOT00000012015.9

    14. XM_039107836.2 → XP_038963764.1  tubulin monoglycylase TTLL3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:439 → 731
      TTL; Tubulin-tyrosine ligase family

    15. XM_063286293.1 → XP_063142363.1  tubulin monoglycylase TTLL3 isoform X5

    16. XM_039107852.2 → XP_038963780.1  tubulin monoglycylase TTLL3 isoform X25

      Conserved Domains (1) summary
      pfam03133
      Location:439 → 731
      TTL; Tubulin-tyrosine ligase family

    17. XM_039107840.2 → XP_038963768.1  tubulin monoglycylase TTLL3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y527
      Conserved Domains (1) summary
      pfam03133
      Location:404 → 708
      TTL; Tubulin-tyrosine ligase family

    18. XM_039107841.2 → XP_038963769.1  tubulin monoglycylase TTLL3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y527
      Conserved Domains (1) summary
      pfam03133
      Location:404 → 696
      TTL; Tubulin-tyrosine ligase family

    19. XM_039107853.2 → XP_038963781.1  tubulin monoglycylase TTLL3 isoform X27

      UniProtKB/TrEMBL
      A0A8I5Y527
      Conserved Domains (1) summary
      pfam03133
      Location:404 → 696
      TTL; Tubulin-tyrosine ligase family

    20. XM_039107835.2 → XP_038963763.1  tubulin monoglycylase TTLL3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:438 → 742
      TTL; Tubulin-tyrosine ligase family

    21. XM_039107855.2 → XP_038963783.1  tubulin monoglycylase TTLL3 isoform X30

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:438 → 730
      TTL; Tubulin-tyrosine ligase family

    22. XM_039107838.2 → XP_038963766.1  tubulin monoglycylase TTLL3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:407 → 711
      TTL; Tubulin-tyrosine ligase family

    23. XM_063286297.1 → XP_063142367.1  tubulin monoglycylase TTLL3 isoform X18

    24. XM_063286294.1 → XP_063142364.1  tubulin monoglycylase TTLL3 isoform X10

    25. XM_063286300.1 → XP_063142370.1  tubulin monoglycylase TTLL3 isoform X22

    26. XM_039107839.2 → XP_038963767.1  tubulin monoglycylase TTLL3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ABR5
      Conserved Domains (1) summary
      pfam03133
      Location:406 → 710
      TTL; Tubulin-tyrosine ligase family

    27. XM_063286296.1 → XP_063142366.1  tubulin monoglycylase TTLL3 isoform X15

    28. XM_039107848.2 → XP_038963776.1  tubulin monoglycylase TTLL3 isoform X20

      Conserved Domains (1) summary
      pfam03133
      Location:258 → 562
      TTL; Tubulin-tyrosine ligase family

    29. XM_039107850.2 → XP_038963778.1  tubulin monoglycylase TTLL3 isoform X23

      Conserved Domains (1) summary
      pfam03133
      Location:237 → 541
      TTL; Tubulin-tyrosine ligase family

    30. XM_039107854.1 → XP_038963782.1  tubulin monoglycylase TTLL3 isoform X29

      Conserved Domains (1) summary
      pfam03133
      Location:1 → 233
      TTL; Tubulin-tyrosine ligase family

    RNA

    1. XR_005503258.2 RNA Sequence

    2. XR_005503259.2 RNA Sequence

    3. XR_010065676.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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