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    Gjc2 gap junction protein, gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497913, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gjc2provided by RGD
    Official Full Name
    gap junction protein, gamma 2provided by RGD
    Primary source
    RGD:1562712
    See related
    EnsemblRapid:ENSRNOG00000038328 AllianceGenome:RGD:1562712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cx47; Gja12
    Summary
    Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of calcium ion transmembrane transport; and positive regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 54.1), Lung (RPKM 12.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gjc2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44462203..44470924, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43962642..43971358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45526740..45535520, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911111 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene guanylate kinase 1 Neighboring gene similar to human chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gap junction channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gap junction channel activity involved in cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gap junction gamma-2 protein
    Names
    connexin-47
    gap junction alpha-12 protein
    gap junction membrane channel protein alpha 12
    gap junction protein, alpha 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100784.1NP_001094254.1  gap junction gamma-2 protein

      See identical proteins and their annotated locations for NP_001094254.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q80XF7
      Related
      ENSRNOP00000064383.1, ENSRNOT00000058362.5
      Conserved Domains (3) summary
      smart00037
      Location:4578
      CNX; Connexin homologues
      smart01089
      Location:222288
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:5289
      Connexin; Connexin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      44462203..44470924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246515.5XP_006246577.1  gap junction gamma-2 protein isoform X3

      See identical proteins and their annotated locations for XP_006246577.1

      UniProtKB/Swiss-Prot
      Q80XF7
      Conserved Domains (3) summary
      smart00037
      Location:4578
      CNX; Connexin homologues
      smart01089
      Location:222288
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:5289
      Connexin; Connexin
    2. XM_039086565.2XP_038942493.1  gap junction gamma-2 protein isoform X1

      Related
      ENSRNOP00000102028.1, ENSRNOT00000167661.1
      Conserved Domains (1) summary
      pfam00029
      Location:96381
      Connexin
    3. XM_063269613.1XP_063125683.1  gap junction gamma-2 protein isoform X2

    4. XM_039086566.2XP_038942494.1  gap junction gamma-2 protein isoform X4

      Conserved Domains (1) summary
      pfam00029
      Location:108198
      Connexin