Ipmk inositol polyphosphate multikinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ipmkprovided by RGD
Official Full Name: inositol polyphosphate multikinaseprovided by RGD
Primary source: RGD:620954
See related: EnsemblRapid:ENSRNOG00000000609 AllianceGenome:RGD:620954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Impk; Ipk2
Summary: Enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity and inositol phosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process; inositol trisphosphate metabolic process; and necroptotic process. Predicted to act upstream of or within neural tube formation. Located in nucleus. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 167.5), Lung (RPKM 48.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (17216151..17250826, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (17216988..17251675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (18457309..18489884, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translocation of IPMK to plasma membrane via docking Dvl3 is important for IPMK to access substrates and generate IP5, activating down-stream signaling.
Title: Dvl3 translocates IPMK to the cell membrane in response to Wnt.
IPK2 and IPK1 act as key determining steps in production of IP5 and IP6, respectively
Title: A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

D20Got11 (e-PCR)
- UniSTS:114795

RH131435 (e-PCR)
- UniSTS:214718

RH129909 (e-PCR)
- UniSTS:213197

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables flavonoid binding	ISO Inferred from Sequence Orthology more info
enables inositol tetrakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5-trisphosphate 6-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in inositol trisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube formation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol polyphosphate multikinase

Names: inositol 1,3,4,6-tetrakisphosphate 5-kinase; inositol polyphosphate kinase 2

NP_599244.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

XP_006256407.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

XP_006256408.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134417.2 → NP_599244.1 inositol polyphosphate multikinase

See identical proteins and their annotated locations for NP_599244.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q99NI4

UniProtKB/TrEMBL

A0A8I6AI58, A6JKN6

Related

ENSRNOP00000093022.2, ENSRNOT00000105838.2

Conserved Domains (1) summary

pfam03770
Location:110 → 391

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

17216151..17250826 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256345.5 → XP_006256407.1 inositol polyphosphate multikinase isoform X1

UniProtKB/TrEMBL

A0A8I6AI58, A0A8L2PZ63

Related

ENSRNOP00000000748.3, ENSRNOT00000000748.5

Conserved Domains (1) summary

pfam03770
Location:111 → 392

IPK; Inositol polyphosphate kinase
XM_006256346.5 → XP_006256408.1 inositol polyphosphate multikinase isoform X2

UniProtKB/TrEMBL

A0A8I6AI58

Conserved Domains (1) summary

pfam03770
Location:69 → 350

IPK; Inositol polyphosphate kinase