Snx3 sorting nexin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snx3provided by RGD
Official Full Name: sorting nexin 3provided by RGD
Primary source: RGD:1595151
See related: EnsemblRapid:ENSRNOG00000046705 AllianceGenome:RGD:1595151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol phosphate binding activity; protein phosphatase binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including endosomal transport; intralumenal vesicle formation; and negative regulation of transport. Predicted to act upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 355.3), Kidney (RPKM 352.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (47574051..47607577)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (45992446..46025361)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (47225382..47263390)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Snx3 (e-PCR), detects polymorphism
- UniSTS:532895

REN49968 (e-PCR)
- UniSTS:374768

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in intralumenal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in late endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane invagination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein to membrane docking	ISO Inferred from Sequence Orthology more info
involved_in protein to membrane docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044283.1 → NP_001037748.1 sorting nexin-3

See identical proteins and their annotated locations for NP_001037748.1

Status: PROVISIONAL

Source sequence(s)

BC107918

UniProtKB/Swiss-Prot

Q5U211

UniProtKB/TrEMBL

A6K6Y8

Related

ENSRNOP00000087527.2, ENSRNOT00000075924.3

Conserved Domains (1) summary

cd07293
Location:28 → 150

PX_SNX3; The phosphoinositide binding Phox Homology domain of Sorting Nexin 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

47574051..47607577

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099063.2 → XP_038954991.1 sorting nexin-3 isoform X1

UniProtKB/TrEMBL

A0A8I6A603, B0BMY2

Related

ENSRNOP00000092005.2, ENSRNOT00000074532.5

Conserved Domains (1) summary

cl02563
Location:28 → 129

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_039099064.2 → XP_038954992.1 sorting nexin-3 isoform X2

Conserved Domains (1) summary

cl02563
Location:28 → 86

PX_domain; The Phox Homology domain, a phosphoinositide binding module