mt-Nd3 NADH dehydrogenase 3, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Nd3provided by RGD
Official Full Name: NADH dehydrogenase 3, mitochondrialprovided by RGD
Primary source: RGD:620557
See related: AllianceGenome:RGD:620557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ND3
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to glucocorticoid stimulus; response to light intensity; and response to oxidative stress. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Used to study Huntington's disease and Parkinson's disease. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. Orthologous to human MT-ND3 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (9451..9798)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (9451..9798)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic Sequence:

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Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain