Yars1 tyrosyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Yars1provided by RGD
Official Full Name: tyrosyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1307616
See related: EnsemblRapid:ENSRNOG00000007213 AllianceGenome:RGD:1307616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Yars
Summary: Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation and tyrosyl-tRNA aminoacylation. Predicted to be located in nuclear body. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 150.9), Liver (RPKM 148.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (146820163..146848377)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (141535815..141564029)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (147375350..147403578)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production.
Title: Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d5rat97 (e-PCR)
- UniSTS:122174

RH142596 (e-PCR)
- UniSTS:231843

RH130408 (e-PCR)
- UniSTS:213692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tyrosine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tyrosine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables tyrosine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables tyrosine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in response to starvation	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in tyrosyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tyrosyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine--tRNA ligase, cytoplasmic

Names: tyrRS; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic

NP_001020867.2

EC 6.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025696.1 → NP_001020867.2 tyrosine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001020867.2

Status: VALIDATED

Source sequence(s)

BC098795

UniProtKB/Swiss-Prot

Q4KM49

UniProtKB/TrEMBL

A6ISH9

Related

ENSRNOP00000107228.1, ENSRNOT00000129477.1

Conserved Domains (3) summary

cd02799
Location:401 → 504

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

TIGR00234
Location:45 → 364

tyrS; tyrosyl-tRNA synthetase

cl00015
Location:44 → 364

nt_trans; nucleotidyl transferase superfamily